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    Review

    The Effect of Psoralea corylifolia (Babchi) on Neuronal Apoptosis Induced by Palmitate in PC12 Cells and its Role in Alzheimer’s Disease: A Review

    Sachin Ranjan1, Nidhi Singh Kushwaha3, Shalini Trivedi2, Neha Tiwari4, Salman Khan1★★ Corresponding author

    1. 1Nanotechnology Lab, Department of Biosciences, Integral University, Lucknow, Uttar Pradesh, INDIA.
    2. 2Ageing Biology Lab, Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, INDIA.
    3. 3Department of Applied Microbiology, Banaras Hindu University, Varanasi, Uttar Pradesh, INDIA.
    4. 4Multidisciplinary Research Unit, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, INDIA.

    CORRESPONDENCE

    Salman Khan

    Nanotechnology Lab, Department of Biosciences, Integral University, Lucknow, Uttar Pradesh, INDIA.

    salmank@iul.ac.in

    Received: 23-06-2023; Accepted: 05-03-2024.

    Volume 21, Issue 1 · pp. 7–26 · PUBLISHED 2025 · DOI: 10.1177/09731296241243132

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Psoralea corylifolia (PC) seed extract (PCE) has been extensively utilized as an herbal drug due to its favorable effects on human health. It’s extracts and active components have demonstrated a variety of biological actions including estrogenic, anticancer, antioxidant, anti-bacterial, anti-depressant, anti-inflammatory and anti-ageing properties. A study of this medicinal herb has major constituents extracted using different plant parts has been depicted and among them, Bakuchiol has the highest ethyl acetate extract content. The mechanism behind PCE’s anti-lipotoxic activity against palmitate (PA)-induced lipotoxicity in PC12 cells was examined. CE therapy not only raised the quantities of mRNA for antioxidant genes such as heme-oxygenase and nuclear factor (erythroid-derived 2)-like 2 but also lowered the production of reactive oxygen species caused by PA. Prenylflavonoids play a unique role in the treatment of Alzheimer’s disease (AD) and can be used as a nootropic agent. This article comprehensively enumerated the literature on the anti-apoptotic effects of PC and its potential pathogenesis in AD.

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      Ranjan, S., Kushwaha, N. S., Trivedi, S., Tiwari, N., & Khan, S. (2025). The Effect of Psoralea corylifolia (Babchi) on Neuronal Apoptosis Induced by Palmitate in PC12 Cells and its Role in Alzheimer’s Disease: A Review. Pharmacognosy Magazine, 21(1), 7–26. https://doi.org/10.1177/09731296241243132