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    Effects of Glechoma longituba (Nakai) Kuprian on Motor and Cognitive Functions in a Traumatic Brain Injury Mice Model

    Jihye Park1, Jang-Hoon Kim1, Jinhyun Bae2, Seogyeong Lee1, Yunseo Lim1, Beom-Joon Lee3, Jae-Woo Park3, Seok-Jae Ko3, Kyungjin Lee2, Youngmin Bu2★★ Corresponding author

    1. 1Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, South Korea.
    2. 2Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.
    3. 3Department of Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

    CORRESPONDENCE

    Youngmin Bu

    Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

    ymbu@khu.ac.kr

    Received: 17-01-2024; Accepted: 18-07-2024.

    Volume 21, Issue 2 · pp. 616–625 · PUBLISHED 2025 · DOI: 10.1177/09731296241282408

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Glechoma longituba (Nakai) Kuprian (GL) is primarily used to treat urinary tract infections and traumatic injuries in traditional medicine in East Asia. Various components of GL are reported to show beneficial activities on brain diseases, including cerebral infarction and brain trauma. We hypothesized that GL extract may potentially have a beneficial effect against traumatic brain injury (TBI) animal model. Objectives: This study aims to investigate the effects of GL extract on TBI mouse model. Materials and Methods: The water extract of GL (GLDW) was obtained by boiling with water. The TBI model was established using ICR mice with controlled cortical impact injury. The experimental groups were divided into sham, control, and three GLDW groups (30–300 mg/kg p.o.). Brain damage, neuronal density, and activated microglial density were evaluated. Motor functional deficits were evaluated using Rotarod test and Balance beam test, and cognitive functional deficits were done using novel object recognition (NOR) test and Y-maze test. Results: Oral administration of GLDW did not reduce brain damage or neuronal death. However, it improved motor and cognitive functions in a dose-dependent manner in both motor tests and NOR test except Y-maze test. Conclusion: GLDW can improve the impairment of motor and cognitive functions induced by TBI, but it does not have a protective effect against brain damage and neuronal death. Further studies are necessary in order to investigate the mechanisms GLDW’s functional recovery effect on TBI.

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      Park, J., Kim, J., Bae, J., Lee, S., Lim, Y., Lee, B., Park, J., Ko, S., Lee, K., & Bu, Y. (2025). Effects of Glechoma longituba (Nakai) Kuprian on Motor and Cognitive Functions in a Traumatic Brain Injury Mice Model. Pharmacognosy Magazine, 21(2), 616–625. https://doi.org/10.1177/09731296241282408