Investigating the Protective Role of Solasodine in Lipopolysaccharide-induced Acute Lung Injury in Rats

ABSTRACT

Background: Acute lung injury (ALI) is an acute inflammatory condition defined by the excessive generation of inflammatory chemicals in lung tissue. Solasodine, a glycoalkaloid isolated from Solanum species, has been proven to exhibit antiinflammatory and anti-spermatogenic activities. Objectives: The present study intended to explore the protective potential of Solasodine on lipopolysaccharide (LPS)- stimulated ALI in rat models. Materials and Methods: The animals were assigned to four groups: Normal control, LPS-induced at 4 mg/kg, Solasodine alone 50 mg/kg, LPS + Solasodine 50 mg/kg. The lung tissue was examined to assess the activities of the lung wet/dry weight ratios, lung myeloperoxidase (MPO), nitric oxide (NO) activity, oxidative stress parameters malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and superoxide dismutase (SOD) along with the histopathological analysis were evaluated. In addition, lactate dehydrogenase (LDH) activity in the bronchoalveolar lavage fluid (BALF), levels of inflammatory cytokines interleukin (IL)-1β, tumor necrosis factor-alpha (TNF-α), IL-6, and neutrophil gelatinase-associated lipocalin (LCN-2) in BALF were determined. Results: The results revealed that Solasodine treatment substantially lowered the wet/dry weight ratio, improved the histopathologic modifications, increased the SOD, and downregulated the levels of LDH, MPO, nitric oxide (NO), MDA, and 8-OHdG. Moreover, Solasodine treatment decreased the neutrophil infiltration and cytokines and protein levels in the BALF. Conclusion: The current investigation suggested that Solasodine improved LPS-stimulated ALI owing to its anti-inflammatory and antioxidative activity in rats. This study’s nursing interventions involve vigilant monitoring, ethical treatment, supportive care, and accurate data collection. Vigilant monitoring detects distress, and ethical treatment minimizes suffering, supportive care includes oxygen therapy, and accurate data collection evaluates Solasodine efficacy.

KEYWORDS

• Acute lung injury
• Solasodine
• lipopolysaccharide
• natural compound
• inflammatory makers
• antioxidant

Showing references and in-text citations exactly as published.

• DOI10.1177/09731296241305943Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Mag..

• Article · VOLUME 21, ISSUE 3Bioflavonoid Tangeretin regulates RANK/RANKL/OPG Signaling Proteins via Stimulating Estrogenic Activity in Ovariectomized RatsWeike Tian, Wei Zhang, Li Chen, Junlei Liao, Xuesong Yang · pp. 1001–1012Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 3PhcogMag 21 3 1013Yanhong Zhang, Yanlong He · pp. 1013–1021Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 3Rosmanol Effectively Prevents Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats by Regulating the PI3K/Akt Signaling PathwayWei Cao, Qi Liu, Ying Wang, Lianfeng Chen · pp. 1022–1033Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 3Liquiritin Promotes Vasodilation Effects by Activating the Kv and KATP Channels in the Isolated Rat Thoracic AortaMengXue Ma, YouLan Che, Xin Yang, Zhi Wang, Ya Wen Bai, Yang Yu, QingBin Xu, Ru Zhou · pp. 1034–1042Original Research ArticleSame type: Article