Volume 21, Issue 3

2025 · pp. 727–1131 · 32 articles

Volume: 21
Issue: 3
Published: 2025
Pages: 727–1131
Articles: 32
Sections: 2
ISSN: ISSN: Print - 0973-1296, Online - 0976-4062
Journal: Pharmacogn. Mag.

Original Research Article Review Article

In this issue

Original Research Article

Article
Bioflavonoid Tangeretin regulates RANK/RANKL/OPG Signaling Proteins via Stimulating Estrogenic Activity in Ovariectomized Rats
Weike Tian, Wei Zhang, Li Chen, Junlei Liao, Xuesong Yang
pp. 1001–1012 · DOI: 10.1177/09731296241296201 · Published 2025
Background: Globally, osteoporosis has arisen as a significant health hazard, impacting over 200 million individuals. It is often reported in women, especially those who are in the postmenopausal stage. Even though numer…
Article
PhcogMag 21 3 1013
Yanhong Zhang, Yanlong He
pp. 1013–1021 · DOI: 10.1177/09731296241307737 · Published 2025
Background: One significant consequence of sepsis and a major factor in death in critical care units is acute lung injury (ALI). Purpurin has been proven in studies to minimize oxidative stress and inflammation. Objectiv…
Article
Rosmanol Effectively Prevents Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats by Regulating the PI3K/Akt Signaling Pathway
Wei Cao, Qi Liu, Ying Wang, Lianfeng Chen
pp. 1022–1033 · DOI: 10.1177/09731296241298349 · Published 2025
Background: Hepatocellular carcinoma (HCC) is the third principal reason for tumor-linked fatalities globally. There is no effective cure for HCC due to rapid progression and poor prognosis. Rosmanol (RM) is a phenolic d…
Article
Liquiritin Promotes Vasodilation Effects by Activating the Kv and KATP Channels in the Isolated Rat Thoracic Aorta
MengXue Ma, YouLan Che, Xin Yang, Zhi Wang, Ya Wen Bai, Yang Yu, QingBin Xu, Ru Zhou
pp. 1034–1042 · DOI: 10.1177/09731296241298360 · Published 2025
Background: Liquiritin, a flavonoid present in the traditional Chinese medicine Radix Glycyrrhizae, reduces myocardial damage and improves cardiac function. However, it remains unclear what effect it has on the thoracic …
Article
Tomatidine, A Promising Steroidal Alkaloid Alleviates Various Noxious Stimuli Induced Nociception in Mice Model
Jiajia Chen, Xi Wang, Dan Wang, Hengming Yin, Guoping Ma
pp. 1077–1089 · DOI: 10.1177/09731296241307746 · Published 2025
Background: Nociception, often described as the body’s ability to sense and respond to harmful stimuli, represents a global discomfort that profoundly impacts individuals across the globe. It functions as a fundamental w…
Article
Efficacy and Safety of Traditional Chinese Medicine Interventions in Unresponsive Mild-to-Moderate Ulcerative Colitis: A Meta-Analysis of Randomized Controlled Trials
Aiyangzi Lu, Yan Sun, Hui Gao, Ping Chen
pp. 1090–1099 · DOI: 10.1177/09731296241307093 · Published 2025
Background: Treatments for ulcerative colitis (UC), a chronic inflammatory bowel illness, have been investigated using Traditional Chinese Medicine (TCM). Uncertainty surrounds the relative safety and effectiveness of TC…
Article
Cardioprotective Potential of Bioactive Compound from Methanolic Extract of Asparagus racemosus: An in silico Study Utilizing GC–MS Analysis
Sandip Sen, Biswabara Roy, N. Kannappan, Khalid Zoghebi, Mohammed Albratty, Hassan A. Alhazmi, Asim Najmi, Md Shamsher Alam
pp. 1100–1113 · DOI: 10.1177/09731296241300873 · Published 2025
Background: Historical accounts suggest that, throughout antiquity, medicinal plants and their constituent parts have been used to treat a variety of ailments. Asparagus racemosus, this plant exhibits a wide range of pot…
Article
Effects of Motherwort on Biological Behavior of Brain Tissue in Rats with Ischemic Stroke and its Relationship with Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway
Guangyu Cao, Jianju Zhou, Guoqing Yu, Xiaohong Fu, Bo Xiong
pp. 1114–1123 · DOI: 10.1177/09731296241296204 · Published 2025
Background: Motherwort has a protective effect on the nervous system and can improve cerebral ischemia–reperfusion injury to a certain extent. However, the effect of motherwort on the biological behavior of the brain tis…
Article
Wogonin Alleviates Aconitine-induced Gastric Tissue Damage in Gastric Cancer through PI3K/Akt Signaling Pathway
Yiyue Fu, Xiaodong Tang, Yichen Hu, Shufeng Zheng
pp. 1124–1131 · DOI: 10.1177/09731296241296601 · Published 2025
Background and Objectives: Aconitine is a toxic substance capable of causing damage to the nervous system, digestive system, and gastric tissue. Wogonin exhibits significant antibacterial, antioxidant, and potential anti…
Article
Evaluation and Analysis of Traditional Chinese Medicine Treatment of Bovine Viral Diarrhea/Mucosal Disease Based on Network Pharmacology and in vitro Studies
Liang Chen, Shijie Lan, Sisi Shen, Jiahui Wang, Xuesong Liu, Botao Jiang, Peng Zhong, Bochao Liu, Shuang Yao, Pingwei Qin, Wanyu Feng
pp. 765–780 · DOI: 10.1177/09731296241276640 · Published 2025
Background: Bovine viral diarrhea/mucosal disease (BVD-MD) is widely distributed worldwide. The disease causes serious economic losses to animal husbandry every year. Finding targeted antiviral drugs proves to be an effe…
Article
Cinnamon Polyphenols Ameliorate the Dysregulation of Cardiac Energy and Autophagic Homeostasis in Rats with Diabetic Cardiomyopathy via the mTOR/PGC1α Pathway
Xu Zhang, Xiao-Ting Zhang, Shi-Yu Wu, Ming-Qiao Hu, Xu Xu, Jian-Ping Gao
pp. 781–792 · DOI: 10.1177/09731296241289678 · Published 2025
Background: Inflammation mediated by hyperglycemia, lipid metabolism disorders, abnormal myocardial energy metabolism, myocardial cell damage, and changes in ventricular structure are important mechanisms in the occurren…
Article
Farnesol Inhibits Cell Viability and Activates Apoptosis in Glioma C6 Cells via Downregulating Phosphoinositide 3-kinase (PI3K)/Protein Kinase B (AKT)/Mammalian Target of Rapamycin (mTOR) Pathway
Chao Gao, Shunzhan Su, Qi Guan, Xiaoxia Huang, Haichuan Tan, Zhuang Qiu, Lili Su, Shengcao Cao
pp. 793–804 · DOI: 10.1177/09731296241305861 · Published 2025
Background: Gliomas are the most aggressive and devastating brain tumors, with a poor prognosis due to their complex etiology, diverse clinical manifestations, and the limited efficacy of existing treatment methods. Obje…
Article
Galangin Ameliorates Gamma Radiationinduced DNA Damage and Subsequent Chromosomal Aberrations in Human Blood Lymphocytes
Huiying Zhao, Yongshou Xia
pp. 805–817 · DOI: 10.1177/09731296241307453 · Published 2025
Background: Natural compounds with radioprotective properties have gained attention due to their potential to reduce health risks associated with radiation exposure. Galangin (GA), a flavonoid recognized for its antioxid…
Article
Cisplatin in Combination with Apigenin Inhibits Human Osteosarcoma Cells Proliferation by Promoting Osteogenic Differentiation: A Mechanistic Insight
Abdullah Alqarni, Jagadish Hosmani, Khalil Assiri, Saeed Alassiri, Ali Mosfer Alqahtani
pp. 818–830 · DOI: 10.1177/09731296241299496 · Published 2025
Background: Osteosarcoma, the predominant primary bone cancer in the pediatric and adolescent population globally, exhibits a relatively low annual incidence but contributes significantly to morbidity and mortality. Obje…
Article
Hyperoside inhibits Mitochondrial DNA Damage to Reverse Hepatocyte Pyroptosis to Treat Doxorubicin-related Hepatotoxicity
Qing Liu, Ying Lan, Zhe Bai
pp. 831–841 · DOI: 10.1177/09731296241306199 · Published 2025
Background: Hyperoside is a potential liver cell and mitochondrial protector, but there is no evidence to suggest that hyperoside can effectively treat doxorubicin (DOX) related liver toxicity. Objectives: This study aim…
Article
The Impact of Culture Time on Genistin and Genistein Accumulation in Flemingia macrophylla (Willd.) Prain Seedlings and the Differentially Expressed Genes
Qiao Ling Yu, Guang Xiu Wu, Kai Wen Tan, Ying Liang, Shuang Shuang Qin, Fan Wei, Jin Yuan Cai, Ling Yun Chen, Guo Yong Xie, Ming Zhai, Kun Hua Wei
pp. 842–854 · DOI: 10.1177/09731296241307086 · Published 2025
Background: Genistein and genistin are the main active constituents of Flemingia macrophylla (Willd.) Prain and the amount of active constituents in the roots varies depending on the cultivation time. The harvesting peri…
Article
Investigating the Protective Role of Solasodine in Lipopolysaccharide-induced Acute Lung Injury in Rats
Xiaoyan Lv, Yanlong He, Yanhong Zhang
pp. 855–864 · DOI: 10.1177/09731296241305943 · Published 2025
Background: Acute lung injury (ALI) is an acute inflammatory condition defined by the excessive generation of inflammatory chemicals in lung tissue. Solasodine, a glycoalkaloid isolated from Solanum species, has been pro…
Article
Puerarin Promotes Tibial Shaft Fracture Healing in Rats and its Relationship with BMP-Smad Pathway
and can further recruit substances such as Smad, its Relationship with BMP-Smad Pathway Yini Mao, Jun Li, Feifei Zhang
pp. 865–876 · DOI: 10.1177/09731296241305868 · Published 2025
Background: Fracture healing involves multiple growth factors and the interaction between multiple signaling pathways. Pue (puerarin) is a natural compound with multiple biological activities, but its effect on fracture …
Article
Investigation of Tribulus terrestris Fruits Extract and Isolated Compound against Metyrapone-induced Adrenal Insufficiency in Wistar Rats
Vakkalagadda Siva Ganesh, Prakash Goudanavar, N Raghavendra Naveen, Girish Meravanige Basavarajappa, Afzal Haq Asif, Predeepkumar Narayanappa Shiroorkar, Bharathi D R, Sreeharsha Nagaraja
pp. 877–884 · DOI: 10.1177/09731296241299495 · Published 2025
Background: Metyrapone inhibits 11 β-hydroxylase, contributing to adrenal insufficiency (AI). This study aims to explore the efficacy of Tribulus terrestris fruit extract (TTFE) and an isolated compound (hecogenin) on me…
Article
Aucubin Regulates Allergic Airway Inflammation in Ovalbumin-induced Allergic Asthma in Mice by Controlling Th2 Cytokines
Lisha Li, Xiaoping Yang, Zhuo Cai, Bin Yin, Wenqing Jiang
pp. 885–894 · DOI: 10.1177/09731296241305864 · Published 2025
Background: Asthma is a chronic inflammatory condition of the airways, leading to excessive production of mucus and an inflammatory condition of the lungs. The primary clinical manifestations of asthma comprise thoracic …
Article
Luteolin-Zinc Modulates PRR11 Methylation and Ferroptosis in Lung Cancer Cells Under Hypoxia
Jiayong Huang, Binbo Fang, Ting Guo, Yiyang Li, Yilin Yang, Jiongcheng Ying, Haoyun Zhou, Xiang Li
pp. 895–905 · DOI: 10.1177/09731296241311343 · Published 2025
Background: Activation of PRR11 contributes to the progression of lung cancer and is related to its methylation status. However, the regulatory mechanism of luteolin-zinc (Lu-Zn) on PRR11 methylation-mediated lung cancer…
Article
Inhibitory Effects of Different Doses of Matrine on Breast Cancer and Its Relationship with miR-188
Zhao Liu, Jian Xu, Heng Xia, Miaofeng Wang, Qianlan Xu
pp. 906–916 · DOI: 10.1177/09731296241311986 · Published 2025
Background: Malignant tumors represented by breast cancer still have limitations in clinical treatment methods. Matrine is a compound with anticancer activity, but its inhibitory effect on breast cancer and its mechanism…
Article
Cedrin Mitigates Dyslipidemia, Inflammation, and Oxidative Stress in Streptozotocin-induced Diabetes Mellitus in Rats
Haiping Zhang, Dan Mei, Meina Li
pp. 917–928 · DOI: 10.1177/09731296241297429 · Published 2025
Background: Cedrin is a major bioactive flavonoid compound present in the Cedrus deodara plant and has been reported to have several biological activities. Diabetes mellitus is an endocrine and metabolic disease marked b…
Article
Anti-inflammatory Effect of Commiphora gileadensis L. Induces Cardiovascular Integrity Markers in Male Diabetic Mice
Ayman Saeed Alhazmi
pp. 929–938 · DOI: 10.1177/09731296241300871 · Published 2025
Background: Cardiovascular disease continues to be a predominant source of morbidity and mortality globally. Commiphora gileadensis L. is a tree under the genus Commiphora. Objectives: To investigate the anti-inflammator…
Article
Linarin Protects against Cisplatin-induced Nephrotoxicity via Subsiding Proinflammatory and Oxidative Stress Biomarkers in Male Wistar Rats
Jie Qi, Lili Gao
pp. 939–947 · DOI: 10.1177/09731296241297432 · Published 2025
Background: One of the most effective anticancer medications for treating a range of cancers is cisplatin (Cis). Its use is limited because of its nephrotoxicity. Objectives: This study aims to evaluate the role of linar…
Article
Eucalyptol Attenuates Cerebral Ischemia/Reperfusion Injury in Mice
Yuning Wang, Dan Wu
pp. 948–958 · DOI: 10.1177/09731296241297431 · Published 2025
Background: One of the leading causes of acute brain injury is cerebral ischemia/reperfusion (I/R) injury. It is an ailment that occurs when the brain does not receive enough oxygen-rich blood supply, which damages brain…
Article
Proliferative Effects of Curcuma zedoaria Extract on Ovarian Tumor Cells
Na Song, Xiuyun Wang, Mingxing Yuan
pp. 959–973 · DOI: 10.1177/09731296241298344 · Published 2025
Background: Curcuma zedoaria is a common traditional herbal medicine that contains mainly curcumin and volatile oils with antioxidant, anti-inflammatory, and antitumor properties. Objectives: This study aimed to investig…
Article
Polystyrene Nanoparticles-coated Astragalus Polysaccharides Affects the Development of Prostate Cancer by Regulating Glycolysis of DAP12/SYK Axis through miR-370
Cheng Gao Gao, Zixiong Liu, Jiafu Tan
pp. 974–983 · DOI: 10.1177/09731296241298361 · Published 2025
Background: This study aims to explore the use of polystyrene nanoparticles as a carrier to encapsulate astragalus polysaccharides and regulate the glycolytic pathway of the DNAX-activating protein of 12 kDa/spleen tyros…
Article
Antiproliferative and Apoptotic Potential of Chicoric Acid, a Major Phytoconstituent of Cichorium intybus, against Colon Cancer Cells: A Possible Inhibition of CDC25 Phosphatases
Modhi O. Alotaibi, Mahima Verma, Shireen Fatima, Nahaa M. Alotaibi, Nawaf Alshammari, Mohd Saeed, F. K. Alharbi, Irfan Ahmad Ansari
pp. 984–1000 · DOI: 10.1177/09731296241291625 · Published 2025
Background: Over the years, plants have been utilized worldwide for the treatment of cancer in the traditional system of medicine, notably in the majority of developing nations. The use of chemotherapeutic drugs is frequ…

Review Article

Review
Pharmacological Activities of Aesculus hippocastanum and its Bioactive Constituents in Hemostasis: A Mechanistic Review
Linyin Yan, Yu Zhang, Decai Dai, Yanqiang Li, Wei Xiao
pp. 727–737 · DOI: 10.1177/09731296241299498 · Published 2025
Hemostatic disorders are the leading cause of morbidity and even mortality worldwide. Therefore, there is a growing tendency to develop novel, effective, and safer agents for the management of hemostatic diseases. Curren…
Review
The Pharmacological Research of Traditional Chinese Medicine and Herbal Remedies in the Treatment of Melanoma
Shuang Yan, Yawei Wang, Jing Zeng, Dan Liu, Haichuan Qin, Chengzhen Du, Qiao Xiang, Li Yang, Ling Li, Yuxin He
pp. 738–750 · DOI: 10.1177/09731296241309963 · Published 2025
Background: Melanoma is a highly invasive and metastatic malignant tumor, with pathogenesis involving multiple signaling pathways and transcription factors. Current treatments face significant challenges, including drug …
Review
Lac Dye: Beyond Textiles and Tradition, A Comprehensive Review of its Bioactive Potential
Pankaj Dagur, Manik Ghosh
pp. 751–764 · DOI: 10.1177/09731296241305858 · Published 2025
Lac has been attracting the scientific community’s attention since time immemorial, aided by its wide-ranging applicability in the textile, plastic, metallurgy, and food industries. Lac exudate comprises three primary co…