Sophoricoside Inhibits Cell Growth and Induces Oxidative Stress-dependent Apoptosis in Colon Cancer HCT-116 Cells
Zheng Zhang1, Qian Zheng2, Dongli Zhang3, Shaowen Li4★★ Corresponding author
- 1Three General Surgery Departments, Baoding First Central Hospital, Baoding, Hebei, CHINA.
- 2Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei, CHINA.
- 3Department of Integrated Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, CHINA.
- 4Medical Examination Center, Affiliated Hospital of Hebei University, Baoding, Hebei, CHINA.
CORRESPONDENCE
Shaowen Li
Medical Examination Center, Affiliated Hospital of Hebei University, Baoding, Hebei, CHINA.
Volume 22, Issue 1 · pp. 334–341 · PUBLISHED 2026 · DOI: 10.1177/09731296251361618
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ABSTRACT
Background: Colorectal cancer constitutes a major global health issue, defined by the unregulated growth of atypical cells in the large intestine or rectum. This intricate disease, resulting from a combination of genetic, environmental, and lifestyle causes, presents a significant risk to persons globally. Objectives: This work was undertaken to study the anti-cancer effects of sophoricoside on colon cancer cells. Materials and Methods: An MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test was employed to study the influence of sophoricoside on the growth of HCT-116 cells. The apoptotic levels in the untreated and sophoricoside-treated HCT-116 cells were evaluated using 4′,6-diamidino-2-phenylindole (DAPI) and dual staining techniques. The concentrations of oxidative stress indicators in the experimental cells were evaluated using the corresponding test kits. Results: The administration of various dosages of sophoricoside significantly suppressed HCT-116 cell proliferation in a dosedependent manner. Sophoricoside treatment significantly enhanced apoptosis in HCT-116 cells, which is evidenced by the DAPI and dual staining assays. It also elevated oxidative stress marker levels by reducing the antioxidants in HCT-116 cells. Conclusion: The present investigation illustrated that sophoricoside possesses anti-cancer activities against colon cancer by reducing cell viability and inducing oxidative stress-dependent apoptosis in HCT-116 cells. Consequently, the present findings indicate sophoricoside as a promising and beneficial alternative for future colon cancer therapy.
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Zhang, Z., Zheng, Q., Zhang, D., & Li, S. (2026). Sophoricoside Inhibits Cell Growth and Induces Oxidative Stress-dependent Apoptosis in Colon Cancer HCT-116 Cells. Pharmacognosy Magazine, 22(1), 334–341. https://doi.org/10.1177/09731296251361618