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    Antimycobacterial, antiviral and cytotoxic studies of Indigofera aspalathoides Vahl

    B. Rajkapoor1★, N. Murugesh2, S. Kavimani4, D.R. Krishna3, V. Ravichandran1, M. Gobinath1, N. Harikrishnan1, J. Vidyasagar3, E. De Clercq5, Scott G. Franzblau6★ Corresponding author

    1. 1Department of Pharmacology, Vel’s College of Pharmacy, Velan Nagar, Pallavaram, Chennai – 600 117, India.
    2. 2Institute of Pharmacology, Madurai Medical College, Madurai – 625 020, India.
    3. 3Cancer and Aging Research Lab, University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009, India.
    4. 4Pharmacy Division, Mother Theresa Institute of Health Science, Pondicherry – 605 006, India.
    5. 5Rega Institute, Katholieke Universiteit Luven, Minderbroadersstrat, B-3000 Luven, Belgium.
    6. 6Institute for Tuberculosis Research, College of Pharmacy, University of Illinois, Chicago, Illinois 60612-723, USA.

    CORRESPONDENCE

    B. Rajkapoor

    Department of Pharmacology, Vel’s College of Pharmacy, Velan Nagar, Pallavaram, Chennai – 600 117, India.

    rajkapoorb@yahoo.co.in

    Volume 3, Issue 11 · pp. 163–164 · PUBLISHED 2007 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Alcohol extract of Indigofera aspalathoides was tested for antimycobacterial activity against Mycobacterium tuberculosis (H37Rv), antiviral activity against HEL Cell culture (herpes simplex virus-1 KOS, herpes simplex virus-2 G, vaccinia virus, vesicular stomatitis virus and herpes simplex virus-TK KOS ACV), HeLa cell culture (vesicular stomatitis virus, coxsackie virus B4 and respiratory syncytial virus) and cytotoxic activity against human epithelial larynx cancer cells (HEp2), human breast cancer (HBL-100) and cervical carcinoma cells (HeLa) cell lines. The results showed that the extract produced 48% inhibition for antimycobacterial and >80 µg/ml of minimum inhibitory concentration against HEL and HeLa cell cultures of antiviral studies. In cytotoxic studies IC50 value of extract were found 117, >300 and 210 µg/ml against HEp2, HBL-100 and HeLa cells respectively. These studies clearly indicate that extract exhibited antimycobacterial, antiviral and cytotoxic activity.

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      Rajkapoor, B., Murugesh, N., Kavimani, S., Krishna, D., Ravichandran, V., Gobinath, M., Harikrishnan, N., Vidyasagar, J., Clercq, E. D., & Franzblau, S. G. (2007). Antimycobacterial, antiviral and cytotoxic studies of Indigofera aspalathoides Vahl. Pharmacognosy Magazine, 3(11), 163–164.