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    Pharmacognosy MagazineNOW IN
    Article

    Evaluation of the antitumor and trypanocidal activities and alkaloid profile in species of Brazilian Cactaceae

    Ligia M. M. Valente1★, Leia A. Scheinvar2, Gilson C. Silva3, Ana P. Antunes3, Flávia A. L. Santos3, Tatiana F. Oliveira3, Marcelo R. R. Tappin3, Francisco R. Neto3, Alberto S. Pereira3, Sergio F. Carvalhaes3, Antonio C. Siani3, Ricardo R. Santos3, Renata O. A. Soares3, Edmir F. Ferreira3, Marcelo Bozza3, Claudia Stutz3, Daniel Gibaldi3★ Corresponding author

    1. 1Departamento de Química Orgânica, Instituto de Química, Centro de Tecnologia, Bloco A, Universidade Federal do Rio de Janeiro, 21941-909, Rio de Janeiro, RJ, Brazil.
    2. 2Jardín Botánico, Instituto de Biologia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Deleg. Coyoacán, CP 04510, DF, México.
    3. 3Instituto de Tecnologia em Fármacos, Fundação Oswaldo Cruz, R. Sizenando Nabuco 100, 21041-250, Rio de Janeiro, RJ, Brazil.

    CORRESPONDENCE

    Ligia M. M. Valente

    Departamento de Química Orgânica, Instituto de Química, Centro de Tecnologia, Bloco A, Universidade Federal do Rio de Janeiro, 21941-909, Rio de Janeiro, RJ, Brazil.

    valente@iq.ufrj.br

    Volume 3, Issue 11 · pp. 167–168 · PUBLISHED 2007 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Brazilian species of five genus of the family Cactaceae were screened for in vitro antitumor activity in a mechanism-based yeast bioassay using DNA repair- or recombination-deficient mutants of the yeast Saccharomyces cerevisiae, and in an assay using six different tumor cells. Whereas some species showed to be selectively active against some tumor cells, all of them were inactive in the S. cerevisiae assay, thus, demonstrating that the antitumor activity is not related either to the DNA damaging and/or to the topoisomerase I and II inhibition mechanisms. An evaluation for trypanocidal activity in trypomastigote forms of Trypanosoma cruzi showed that three species were especially active. The determination of the alkaloid profile of four species through TLC, HT-HRGC, HT-HRGC-MS and HPLC-PAD revealed, in all the species, low concentrations of alkaloids in complex mixtures with no major compounds.

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      Valente, L. M. M., Scheinvar, L. A., Silva, G. C., Antunes, A. P., Santos, F. A. L., Oliveira, T. F., Tappin, M. R. R., Neto, F. R., Pereira, A. S., Carvalhaes, S. F., Siani, A. C., Santos, R. R., Soares, R. O. A., Ferreira, E. F., Bozza, M., Stutz, C., & Gibaldi, D. (2007). Evaluation of the antitumor and trypanocidal activities and alkaloid profile in species of Brazilian Cactaceae. Pharmacognosy Magazine, 3(11), 167–168.