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    Pharmacognosy MagazineNOW IN
    Article

    Cytotoxic activity of Bulgarian Linum species

    I. Ionkova1★, I. Antonova1, G. Momekov1, E. Fuss2★ Corresponding author

    1. 1Faculty of Pharmacy, Medical University of Sofia, Dunav Str. 2, 1000 Sofia, Bulgaria.
    2. 2Heinrich-Heine-Universität Düsseldorf, Institut für Entwicklungs- und Molekularbiologie der Pflanzen, Universitätsstr. 1, 40225 Düsseldorf, Germany.

    CORRESPONDENCE

    I. Ionkova

    Faculty of Pharmacy, Medical University of Sofia, Dunav Str. 2, 1000 Sofia, Bulgaria.

    ionkova@pharmfac.acad.bg

    Volume 3, Issue 11 · pp. 192–193 · PUBLISHED 2007 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    As part of our ongoing program on the investigation of lignans and their cytotoxic activity in Bulgarian Linum species, extracts of the aerial parts of L. tauricum ssp. linearifolium and L. elegans both endemic in the Balkan area were examined. The aryltetralin lignan 6-methoxypodophyllotoxin (MPTOX) is the main lignan in the extract from L. elegans with about 2 mg/g dry weight. Podophyllotoxin (PTOX) is the main lignan in the extract from L. tauricum ssp. lineraifolium with about 8 mg/g dry weight. The cytotoxicity of the extracts from both species was measured using the MTT–dye assay on human leukemic cell lines. Both showed moderate cytotoxic activity.

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      Ionkova, I., Antonova, I., Momekov, G., & Fuss, E. (2007). Cytotoxic activity of Bulgarian Linum species. Pharmacognosy Magazine, 3(11), 192–193.