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    Zinc administration modulates radiation-induced oxidative injury in lens of rat

    Seyithan Taysi1★, Seydi Okumus2, Mehmet Akyuz3, Naim Uzun4, Adnan Aksoy5, Elif Demir1, Mustafa Orkmez1, Mehmet Tarakcioglu1, Mustafa Adli6★ Corresponding author

    1. 1Departments of Medical Biochemistry, University, Medical School, Gaziantep, Turkey.
    2. 2Ophthalmology and, Turkey.
    3. 3Department of Chemistry, Science and Art Faculty, Kilis 7 Aralık University, Kilis, Turkey.
    4. 4Department of Biochemistry, Ataturk University, School of Medicine, Erzurum, Turkey.
    5. 5Department of Ophthalmology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
    6. 6Radiation Oncology, Gaziantep University, Medical School, Gaziantep, Turkey.

    CORRESPONDENCE

    Seyithan Taysi

    Departments of Medical Biochemistry, University, Medical School, Gaziantep, Turkey.

    Received: 30-11-2011; Revised: 24-01-2012.

    Volume 8, Issue 32 · pp. 245–249 · PUBLISHED 22 November 2012 · DOI: 10.4103/0973-1296.103646

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The aim of this study was to evaluate the antioxidant role of zinc (Zn) against radiation-induced cataract in the rat lens after total cranial irradiation with a single 5 Gray (Gy) dose of gamma irradiation. Materials and Methods: Twenty-one Sprague-Dawley rats were used for the experiment. The control group did not receive Zn or irradiation but received 1-ml saline orally plus sham-irradiation. The irradiation (IR) group received 5 Gy gamma irradiation to the total cranium as a single dose plus 0.1 ml physiological saline intraperitoneally. The IR plus Zn group received irradiation to total cranium plus 10 mg/kg/day Zn intraperitoneally. Biochemical parameters measured in rat lenses were carried out using spectrophotometric techniques. Results: Lens total (enzymatic plus non-enzymatic) superoxide scavenger activity (TSSA), glutathione reductase (GRD), and glutathione-S-transferase (GST) activities significantly increased in the IR plus Zn groups when compared with the IR group. However, TSSA, GRD and GST activities were significantly lower in the IR group when compared with the control group. Lens non-enzymatic superoxide scavenger activity (NSSA) in the IR plus Zn group was significantly increased compared to that of the IR group. Lens xanthine oxidase (XO) activity in the IR group significantly increased compared to that of both the control and IR plus Zn groups. Conclusion: Zn has clear antioxidant properties and prevented oxidative stress by scavenging free radicals generated by ionizing radiation in rat lenses.

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      Taysi, S., Okumus, S., Akyuz, M., Uzun, N., Aksoy, A., Demir, E., Orkmez, M., Tarakcioglu, M., & Adli, M. (2012). Zinc administration modulates radiation-induced oxidative injury in lens of rat. Pharmacognosy Magazine, 8(32), 245–249. https://doi.org/10.4103/0973-1296.103646