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    Article

    Clinical Evaluation of Commiphora Mukul, a Botanical resin, in the Management of Hemorrhoids: A randomized controlled trial

    Mahdi Yousefi1★, Mohammad Reza Vaez Mahdavi2, Seyed Mousalreza Hosseini3, Abdollah Bahrami4, Ali Davati5, Mohammad Kamalinejad6, Sograt Faghihzadeh7★ Corresponding author

    1. 1Department of Traditional Iranian Medicine, Faculty of Medicine, Shahed University, Tehran, Iran.
    2. 2Department of Physiology, Faculty of Medicine, Research Center for Clinical Trial on Traditional Iranian Medicine (RCCT-TIM), Shahed University, Iran.
    3. 3Department of Gastroenterology and Hepatology, Ghaem Hospital, and, Iran.
    4. 4Department of Internal Medicine, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    5. 5Department of Social Medicine, Faculty of Medicine, Shahed University, Iran.
    6. 6Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    7. 7Department of Biostatistics, Zanjan University of Medical Sciences, Zanjan, Iran.

    CORRESPONDENCE

    Mahdi Yousefi

    Department of Traditional Iranian Medicine, Faculty of Medicine, Shahed University, Tehran, Iran.

    vaezmahdavi@shahed.ac.ir

    Received: 11-08-2012; Revised: 19-09-2012.

    Volume 9, Issue 36 · pp. 350–356 · PUBLISHED 7 September 2013 · DOI: 10.4103/0973-1296.117832

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Hemorrhoids complaint is one of the most common problems in most society, especially in Asian countries. Current drug treatment protocols cannot cure the disease, and they are palliative. According to Persian traditional medicine, Commiphora Mukul (CM) resin is a medication choice. Aim: This randomized study was undertaken to evaluate the effi cacy and safety of crude CM resin compared to a combination of lactolose and anti-hemorrhoid (LandA) in patients with uncomplicated hemorrhoids grade 1 and 2. Materials and Methods: This trial was carried out on 99 patients with hemorrhoids, in Ghaem and Imam Reaza Hospitals of the Mashhad University of Medical Sciences, Iran. They randomly received CM 3 g/d for 4 weeks (as study group) or LandA (Lactolose syrup in laxative dose for 1 month and anti-hemorrhoid suppository daily for 10 days) as control group. Subjective and objectives variables including painful defecation, fl atulence, constipation, gastro-esophageal refl ux (GER), dyspepsia, proctorrhagia, anal protrusion, and colonoscopic grading were assessed before, immediately after, and 4 weeks after the treatment period. An intent-to-treat analysis was used. Safety was assessed with evaluation of clinical adverse effects by common toxicity criteria version 4.0. Forty-nine patients were assigned randomly to receive LandA and 50 to receive CM. After 4 weeks, fl atulence, dyspepsia, GER, and colonoscopic grading scores signifi cantly decreased in study group, whereas in control group constipation, painful defecation, and proctorrhagia showed better but not signifi cant improvement. After 4-weak follow-up, the rate of constipation, and proctorrhagia also showed signifi cantly improvement in study group. Constipation and proctorrhagia in control group recurred signifi cantly in 4-week follow-up than after the treatment, whereas this recurrence in test group was not seen. Conclusion: CM was more effective than LandA in 4-week treatment of patients with uncomplicated hemorrhoids grade 1 and 2.

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      Yousefi, M., Mahdavi, M. R. V., Hosseini, S. M., Bahrami, A., Davati, A., Kamalinejad, M., & Faghihzadeh, S. (2013). Clinical Evaluation of Commiphora Mukul, a Botanical resin, in the Management of Hemorrhoids: A randomized controlled trial. Pharmacognosy Magazine, 9(36), 350–356. https://doi.org/10.4103/0973-1296.117832