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    Article

    Effect of NR-Salacia on post-prandial hyperglycemia: A randomized double blind, placebo-controlled, crossover study in healthy volunteers

    Pravina Koteshwar1, Kadur Ramamurthy Raveendra2, Joseph Joshua Allan3★, Krishnagouda Shankargouda Goudar3, Kudiganti Venkateshwarlu3, Amit Agarwal3★ Corresponding author

    1. 1Clinical Pharmacology, Institute of Clinical Research (India), Bangalore.
    2. 2Department of Medicine, Srinivasa Diabetic Research Centre, Bangalore, Institute of Clinical Research (India), Bangalore.
    3. 3Department of Pharmacology and Toxicology, Natural Remedies, Bangalore, Institute of Clinical Research (India), Bangalore, India.

    CORRESPONDENCE

    Joseph Joshua Allan

    Department of Pharmacology and Toxicology, Natural Remedies, Bangalore, Institute of Clinical Research (India), Bangalore, India.

    joshua@naturalremedy.com

    Received: 13-07-2012; Revised: 06-10-2012.

    Volume 9, Issue 36 · pp. 344–349 · PUBLISHED 7 September 2013 · DOI: 10.4103/0973-1296.117831

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Salacia chinensis (S. chinensis) is widely distributed in India and Sri Lanka. Most of the species of genus Salacia are known to have effects on blood glucose levels; however, the effects of S. chinensis on glucose levels are seldom reported. Objective: To evaluate the oral hypoglycemic activity of NR- Salacia (1000 mg extract of S. chinensis) in healthy adults. Materials and Methods: Randomized, double-blind, placebo-controlled, cross-over study was conducted in healthy volunteers. Single dose of NR-Salacia (1000 mg extract of Salacia chinensis) and placebo were administered before carbohydrate-rich diet. A 6-point plasma glucose profi le was performed at different time intervals up to 180 min. Results: NR-Salacia treatment signifi cantly lowered plasma glucose level at 90 min, and the percentage reduction in glucose concentration was found to be 13.32 as compared to placebo group. A 33.85% decrease in the plasma glucose positive incremental area under curve (AUC) (0 to 180 min) was observed in comparison to placebo. No adverse events were recorded throughout the study period, except for some mild cases of abdominal discomforts like cramping and distention, vomiting, and headache in both placebo and NR-Salacia-treated groups. Conclusion: The study fi ndings revealed that NR-Salacia lowered the post-prandial plasma glucose levels after a carbohydrate-rich meal and can be used as an oral hypoglycemic agent.

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      Koteshwar, P., Raveendra, K. R., Allan, J. J., Goudar, K. S., Venkateshwarlu, K., & Agarwal, A. (2013). Effect of NR-Salacia on post-prandial hyperglycemia: A randomized double blind, placebo-controlled, crossover study in healthy volunteers. Pharmacognosy Magazine, 9(36), 344–349. https://doi.org/10.4103/0973-1296.117831