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    Formulation development, optimization and evaluation of aloe vera gel for wound healing

    Abdul Wadood Khan1★, Sabna Kotta1, Shahid Hussain Ansari2, Rakesh Kumar Sharma3, Amit Kumar3, Javed Ali1★ Corresponding author

    1. 1Departments of Pharmaceutics, Institute of Nuclear Medicine and Allied Sciences, Brig S K Muzumdar Marg, New Delhi, India.
    2. 2Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
    3. 3Institute of Nuclear Medicine and Allied Sciences, Brig S K Muzumdar Marg, New Delhi, India.

    CORRESPONDENCE

    Abdul Wadood Khan

    Departments of Pharmaceutics, Institute of Nuclear Medicine and Allied Sciences, Brig S K Muzumdar Marg, New Delhi, India.

    Received: 29-08-2012; Revised: 01-10-2012.

    Volume 9, Issue 36s · pp. 6–10 · PUBLISHED 7 September 2013 · DOI: 10.4103/0973-1296.117849

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Purpose: To formulate and optimize a herbal gel of Aloe vera extract containing Carbopol 934 as gelling agent and to investigate the effects of topical application of Carbopol 934 gel containing Aloe vera extract on the healing of skin wounds surgically induced in Wistar rats. Materials and Methods: Different concentrations of viscosity enhancer Carbopol 934 were tried and finally gel that showed good spreadability and consistency was selected for wound healing property of herbal gel of Aloe vera. Excision wound model was used for the study. Results: The optimized gel was evaluated for different physicochemical properties and wound healing property. Differences in wound healing were observed between the various treatments when compared to the control group. Tissue hyperplasia was lower in the control group compared to the other treated groups. In animals group treated with gel, 80.14% healing was observed up to 14th day. While in untreated group I (control) animals showed 52.68% healing of wounds on 14th day. On the other hand, control group animals also showed inflammation and pus formation up to 5th day of study, while treated animals did not showed any observable inflammation and pus formation. Conclusion: Results shows prepared gel has promising effect on the wound healing process.

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      Khan, A. W., Kotta, S., Ansari, S. H., Sharma, R. K., Kumar, A., & Ali, J. (2013). Formulation development, optimization and evaluation of aloe vera gel for wound healing. Pharmacognosy Magazine, 9(36s), 6–10. https://doi.org/10.4103/0973-1296.117849