Anti-leukemia Activity of Methanolic Extracts of Lantana camara
Badakhshan Mahdi Pour1★, Sreenivasan Sasidharan1, Rameshwar Naidu Jegathambigai1, Ramanathan Surash2★ Corresponding author
- 1Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah, Malaysia. Emails: srisasidharan@yahoo.com, jegathas@yahoo.com.
- 2Centre for Drug Research, University Science of Malaysia, 11800 Minden, Pulau Pinang. Malaysia. Email: srama@usm.my
Received: 22-06-2009; Revised: 17-07-2009; Accepted: 22-08-2009.
Volume 1, Issue 5 · pp. 274–279 · PUBLISHED Sep-Oct 2009 · DOI:
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ABSTRACT
Anticancer effect of Lantana camara’s root and leaf extracts against Jurkat leukemia cell line was investigated by MTT assay. These extracts had statistically similar antineoplastic property (root IC50, 328.36 ± 53.08 μg/ml; leaf, 394.41 ± 99.73 μg/ml; p > 0.1, n = 3), averagely 1/10 times as activity as carboplatin (IC50 34.83 ± 3.60 μg/ml; p < 0.05, n = 3). Decreasing cytotoxicity at higher concentrations implied the existence of cytoprotective compounds. Morphological examinations indicated apoptosis induction as the mechanism of activity on Jurkat cells. In conclusion, L. camara’s root and leaf extracts might be subjects for further fractionation and identification to find new anticancer agents.
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Pour, B. M., Sasidharan, S., Jegathambigai, R. N., & Surash, R. (2009). Anti-leukemia Activity of Methanolic Extracts of Lantana camara. Pharmacognosy Research, 1(5), 274–279.