Antimicrobial and Resistance Modulatory Activities of Corynanthe pachyceras
Adu Francis1★, Gbedema Stephen Yao1, Annan Kofi2★ Corresponding author
- 1Department of Pharmaceutics;
- 2Department of Pharmacognosy, College of Health Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Received: 23-05-2009; Revised: 10-06-2009; Accepted: 22-08-2009.
Volume 1, Issue 5 · pp. 280–284 · PUBLISHED Sep-Oct 2009 · DOI:
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ABSTRACT
As part of the project to identify plant natural products which modulate bacterial multidrug resistance (MDR) the methanol extract of Corynanthe pachyceras (Rubiaceae) K. Schum., were tested for in vitro antibacterial and resistance modifying activities against different bacterial strains including resistant staphylococcus SA1199B, RN4220 and XU212 possessing the Tet(K), Msr(A), and Nor(A) multidrug resistance efflux mechanisms respectively. Using the Micro-well dilution method the MIC of the stem bark extract ranged between 128-512μg/ml against the selected bacteria used. At 10μg/ml, none of the different extracts displayed any antibacterial action but in combination with tetracycline, erythromycin and norfloxacin, the stem bark extract displayed a 2-fold, 4-fold and 8-fold potentiation of activities of these antibiotics against XU212, SA1199B and RN4220 possessing the Tet(K) [tetracycline resistant], Nor(A) [norfloxacin resistant] and Msr(A) [macrolide resistant] transporters respectively.
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Francis, A., Yao, G. S., & Kofi, A. (2009). Antimicrobial and Resistance Modulatory Activities of Corynanthe pachyceras. Pharmacognosy Research, 1(5), 280–284.