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    Chemical constituents and bioactivities of Malabaila suaveolens

    I. Nassar Mahmoud1★, A. Aboutabl El-Sayed2, A. Maklad Yousreya3, A. El-Khrisy Ezzel-Din1, F. Osman Abeer1★ Corresponding author

    1. 1aChemistry of Natural Compounds Department, National Research Centre, 12622 Dokki, Cairo, Egypt.
    2. 2bPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-el-Aini Street, 11562 Cairo, Egypt.
    3. 3cPharmaceutical and Medicinal Chemistry Department, National Research Centre, 12622 Dokki, Cairo, Egypt.

    CORRESPONDENCE

    I. Nassar Mahmoud

    *Telephone: 20222337651; Fax: 20233370931.

    mnassar_eg@yahoo.com

    Received: 29-08-2009; Revised: 05-09-2009; Accepted: 25-09-2009.

    Volume 1, Issue 6 · pp. 342–347 · PUBLISHED Nov-Dec 2009 · DOI:

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Volatile oil components, fatty acids, β-amyrin, and sterols were identified in the n-hexane extract of Malabaila suaveolens Coss. fruits. Angelicin, 4,7,9-trimethyl psoralen, isopimpinellin and umbelliferone were isolated from the dichloromethane extract of the plant. 5-Hydroxy 7, 3`, 4`-trimethoxyflavone, apigenin and its 7-O-β-D-glucopyranoside were isolated from the ethyl acetate extract. From the methanol extract, a new flavonoid, apigenin 7-O-(6``-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), along with vicenin 2, acacetin 7-O-rutinoside, and 6-hydroxyapigenin 7-O-β-D-glucopyranoside were isolated. Toxicity study of n-hexane, dichloromethane, ethyl acetate extract and methanolic extracts of the plant proved that it is relatively nontoxic. The tested extracts showed significant analgesic and anti-inflammatory effects as compared with control groups and reference drugs. Also, the tested extracts showed significant antioxidant activity as compared with reference.

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      Mahmoud, I. N., El-Sayed, A. A., Yousreya, A. M., Ezzel-Din, A. E., & Abeer, F. O. (2009). Chemical constituents and bioactivities of Malabaila suaveolens. Pharmacognosy Research, 1(6), 342–347.