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    Chemical Composition, Antioxidant, and Anticholine Esterase Activities of Essential Oil of Xylopia aethiopica Seeds

    Lateef Adegboyega Sulaimon1★, Rahmat Adetutu Adisa2, Efereo Martins Obuotor3, Modinat Olasunkanmi Lawal1, Abdullahi I Moshood1, Nura H Muhammad1★ Corresponding author

    1. 1Department of Chemical Sciences, Crescent University, Abeokuta, NIGERIA.
    2. 2Department of Biochemistry, University of Lagos, Lagos, NIGERIA.
    3. 3Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, NIGERIA.

    CORRESPONDENCE

    Lateef Adegboyega Sulaimon

    Department of Chemical Sciences, Crescent University, Abeokuta, NIGERIA.

    adlat4best@yahoo.com

    Volume 12, Issue 2 · pp. 112–118 · PUBLISHED · DOI: 10.4103/pr.pr_47_19

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: Xylopia aethiopica is well known to treat neurodegenerative diseases in traditional medicine and there is no scientific evidence for this claim. Objective: The current research aimed at investigating chemical characterization, antioxidant, and anticholine esterase activity of the essential oil fromX. aethiopica.Materials and Methods:Essential oil extraction was carried out by the use of the steam distillation method in a modified Clevenger‑type apparatus. The chemical composition of the essential oil from seeds of X. aethiopica (African pepper) was determined using gas chromatography coupled with mass spectrometry (GC‑MS) and its potentials as antioxidant and anticholine esterase were evaluated for the first time. Results:The oil yield was 5.2% (v/w) in X. aethiopica. The GC‑MS analysis identified a total of 52 compounds corresponding to 100% of the total oil in X. aethiopica.The major constituents ofX. aethiopicaessential oil are terpinen‑4‑ol (11.88%), α‑terpineol (5.93%), cyclohexane methanol (4.79%), and β‑copaene (4.74%). The most abundant classes of compounds from the essential oil were oxygenated monoterpenes (MT) which amounted to (37.6%), followed by oxygenated sesquiterpenes (29.61%), sesquiterpenes (14.67%), oxygenated diterpenes (9.05%), nonterpenoid aliphatic and aromatic hydrocarbons (4.81%), diterpenes (3.8%), and MT (0.47%) of all the identified constituents. A significant antioxidant (IC50 value of 2,2‑diphenyl‑1‑picrylhydrazyl = 2.19 ± 0.09 mg/mL) and anticholine esterase activity (IC50 = 1.21 ± 0.06 mg/mL) was obtained for the essential oil ofX. aethiopica. Conclusion: The study established the chemical composition, antioxidant, and anticholine esterase activities of the essential oil of the plant seeds.

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      Sulaimon, L. A., Adisa, R. A., Obuotor, E. M., Lawal, M. O., Moshood, A. I., & Muhammad, N. H. (). Chemical Composition, Antioxidant, and Anticholine Esterase Activities of Essential Oil of Xylopia aethiopica Seeds. Pharmacognosy Research, 12(2), 112–118. https://doi.org/10.4103/pr.pr_47_19