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    Antifungal Screening of Surveyed Plants of Gwadabawa/Illela Communities of Sokoto State-Northwest Nigeria

    Mathias Sylvester Nefai1★, Mshelia Halilu Emanuel2, Giaze Tijani Rabiu3, Hussain Yahaya Ungo-Kore4★ Corresponding author

    1. 1Department of Pharmacognosy and Ethnopharmacy, Usmanu Danfodiyo University, Sokoto, NIGERIA.
    2. 2Faculty of Pharmacy, Cyprus International University, Haspolat/Nicosia, Mersin, TURKEY.
    3. 3Department of Pharmacology and Toxicology, Usmanu Danfodiyo University, Sokoto, NIGERIA.
    4. 4Department of Pharmaceutical Microbiology, Usmanu Danfodiyo University, Sokoto, NIGERIA.

    CORRESPONDENCE

    Mathias Sylvester Nefai

    Department of Pharmacognosy and Ethnopharmacy, Usmanu Danfodiyo University, Sokoto, NIGERIA.

    nefai74ng@gmail.com

    Received: 15-07-2022; Revised: 29-08-2022; Accepted: 19-09-2022.

    Volume 14, Issue 4 · pp. 417–422 · PUBLISHED · DOI: 10.5530/pres.14.4.61

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:An earlier ethnobotanical study afforded fifteen surveyed plants, which are used as antifungal and wound healing remedies. This informed their antifungal screening to validate folklore claims. Materials and Methods:Identified, procured, and authenticated medicinal plants were each, defatted in hexane and extracted with methanol before partitioning with n-butanol to obtain an n-butanol extract with solubilized antifungal compounds in the organic phase. The resulting concentrated n-butanol extracts were then screened by subjecting each plant extract to in vitroantifungal assay for the determination of the minimum inhibitory concentration (MIC) of the extract on Aspergillus nigerin a 96-well flat bottom polystyrene microtiter plate using the broth microdilution method as outlined in the 2021 Clinical and Laboratory Standard Institute guideline. Results:The antifungal screening of the plants presented active plant extracts with variable antifungal properties of MIC values ranging from 3.9 to 250 (mg/ml). Only the extract of Balanites aegypticashowed no activity at all concentrations tested. The lowest extreme was recorded for Ficus Platyphylla, which gave a slight activity at the highest MIC of 125mg/ml, while the highest activity was recorded for Faidherbia albidaat the lowest test concentration with a MIC of 3.90625 mg/ml. The other thirteen extracts exhibited antifungal activity in varying degree with the following MICs: Stecullia setigera(7.8125 mg/ml), Annona senegalensis(7.8125 mg/ml), Uraria picta(7.8125 mg/ml) Combretum collinum(15.65 mg/ml), Afromosia lexiflora(15.65 mg/ml), Waltheria indica(15.65 mg/ml), Guiera senegalensis(15.65 mg/ml), Carica papaya(31.25 mg/ml),Rogeria adenophylla(31.25 mg/ml), Pennisetum hordeoides(31.25 mg/ml), Acacia nilotica(31.25 mg/ml) and Sida ovata(62.5 mg/ml). Conclusion:The in vitroantifungal potential of these surveyed plants supports their traditional use, hence, information (data) furnished by this study can be exploited for their further evaluations as antimicrobial drug leads of nature.

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      Nefai, M. S., Emanuel, M. H., Rabiu, G. T., & Ungo-Kore, H. Y. (). Antifungal Screening of Surveyed Plants of Gwadabawa/Illela Communities of Sokoto State-Northwest Nigeria. Pharmacognosy Research, 14(4), 417–422. https://doi.org/10.5530/pres.14.4.61