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    Anti-arthritic and Anti-inflammatory Activity of Ayurvedic Polyherbal Formulation in Laboratory Animals

    Chandrasekar Sandanapalli Basavarajaiah1,2★, Anil Tukaram Pawar1,3, Harisha Ramappa4, Vani Setty2,5★ Corresponding author

    1. 1Department of Pharmacology, Acharya & BM Reddy College of Pharmacy, Soladevanalli, Bangalore, Karnataka, INDIA.
    2. 2Department of Drugs Control, Drugs Testing Laboratory, Government of Karnataka, Palace Road, Bangalore, Karnataka, INDIA.
    3. 3Department of Pharmaceutical Sciences, School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, INDIA.
    4. 4Department of Pharmacology, Government College of Pharmacy, Subbaiah Circle, Bangalore, Karnataka, INDIA.
    5. 5School of Pharmacy, Sri Balaji Vidyapeeth, SBV Campus, Pillaiyarkuppam, Pondicherry, INDIA.

    CORRESPONDENCE

    Chandrasekar Sandanapalli Basavarajaiah

    Department of Pharmacology, Acharya & BM Reddy College of Pharmacy, Soladevanalli, Bangalore, Karnataka, INDIA.

    dtlsbcs@gmail.com

    Received: 25-07-2023; Revised: 11-08-2023; Accepted: 29-09-2023.

    Volume 16, Issue 1 · pp. 110–117 · PUBLISHED · DOI: 10.5530/pres.16.1.13

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:RD/M.ph.AA-01 is an Ayurvedic polyherbal formulation, developed foramavata, which is associated with chronic inflammatory autoimmune diseases. Objectives: The study was planned to evaluate the anti-arthritic and anti-inflammatory activity of RD/M.ph.AA-01 in laboratory animals.Materials and Methods: Anti-arthritic activity of RD/M.ph.AA-01 was evaluated at 270 and 405 mg/kg doses against Complete Freund’s Adjuvant (CFA)-induced arthritis. Anti-inflammatory activity was studied using cotton pellet granuloma and formalin-induced edema in rat models. The effect of topical application of RD/M.ph.AA-01 on Croton oil ear edema in mice was also investigated. Results: Arthritis induction caused a significant (p<0.05) alteration in paw size, hematology, serum parameters, edematous tissue parameters, lipid peroxidation in the liver and histopathology of joints. These alterations were significantly (p<0.05) prevented by treatment with RD/M.ph.AA-01. In the cotton pellet granuloma, RD/M. ph.AA-01 supplementation caused significant (p<0.05) improvement in the weight of granuloma tissue, serum parameters, lipid peroxidation in the liver and histopathological changes in granuloma tissue. A significant (p<0.05) improvement in paw size, serum parameters and liver lipid peroxidation were observed by RD/M.ph.AA-01 treatment in the formalin-induced edema model. The RD/M.ph.AA-01 also significantly (p<0.05) suppressed Croton oil-induced ear edema.Conclusion:These findings showed that RD/M.ph.AA-01 possesses potent anti-arthritic and anti-inflammatory activity.

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      Basavarajaiah, C. S., Pawar, A. T., Ramappa, H., & Setty, V. (). Anti-arthritic and Anti-inflammatory Activity of Ayurvedic Polyherbal Formulation in Laboratory Animals. Pharmacognosy Research, 16(1), 110–117. https://doi.org/10.5530/pres.16.1.13