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    Camel Milk Supplemented with Fenugreek Seeds Improve Lipid Profile, Atherogenic Index and Antioxidative Status in Animal Model of Cardiovascular Disorders

    Sami A. Althwab1, Thekra A. Alharby1, Waleed Al Abdulmonem2★, Khalid H. Musa1, Zafar Rasheed2, Abdullah S. M. Aljohani3, Mona S. Almujaydil1, Bashayr Y. Alghonaim1, Nasser A. Alharbi1, Ala Al Rajabi4, Muhammad Ismail Khan5, Nelson Fernández6, Essam M. Hamad1,7★ Corresponding author

    1. 1Department of Food Science and Human Nutrition, College of Agriculture and Food, Qassim University, Buraidah, SAUDI ARABIA.
    2. 2Department of Pathology, College of Medicine, Qassim University, Buraidah, SAUDI ARABIA.
    3. 3Department of Medical Biosciences, College of Veterinary Medicine, Qassim University, Buraydah, SAUDI ARABIA.
    4. 4Department of Human Nutrition, College of Health Science, Qatar University, Doha, QATAR.
    5. 5Faculty of Medicine, School of Public Health, University of Queensland, Brisbane, AUSTRALIA.
    6. 6School of Life Sciences, University of Essex, Colchester, UNITED KINGDOM.
    7. 7Department of Dairy Science, Faculty of Agriculture, Cairo University, EGYPT.

    CORRESPONDENCE

    Waleed Al Abdulmonem

    Department of Pathology, College of Medicine, Qassim University, Buraidah, SAUDI ARABIA.

    dr.waleedmonem@qu.edu.sa

    Received: 10-04-2023; Revised: 10-05-2023; Accepted: 12-06-2023.

    Volume 16, Issue 3 · pp. 483–489 · PUBLISHED · DOI: 10.5530/pres.16.3.58

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: Despite of advancement in the technology and an improvement in handing of patients with atherosclerosis and Cardiovascular Diseases (CVDs) but the mortality associated with them remains to be highest in all over the globe. The Atherogenic Index of Plasma (AIP) has now been considered to be a best indicator for the analysis of atherosclerosis and CVDs. This study was undertaken to investigate the potential of Fermented camel Milk (FM) and Fenugreek seed powder (FG) on the animal model of CVDs.Materials and Methods: The animal models of atherosclerosis and CVDs were made by feeding of rats with high fat and cholesterol diets and the effect of FM supplemented with FG either alone or in a combination (FGFM) were tested on the lipid profile and AIP by Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), Glutathione Peroxidase (GPx) activity, Total Cholesterol (TC) and small dense Low-Density Lipoprotein (sd-LDL). Results: The data revealed that FM, FG and their combination potentially increased in TAC level (p<0.05) and decreased in lipid peroxidation via reduction in the serum concentrations of MDA. Whereas, experimental rats on FM were fully restored GPx activity. Moreover, FM and FG and their combination lowered TC and sd-LDL concentrations significantly (p<0.05). Conclusion: The novel findings of this study clearly indicated that the FG, FM and FGFM have potential in preventing the onset of atherosclerosis and CVDs by reducing the levels of sd-LDL and improving lipids profile, AIP and antioxidant capacity.

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      Althwab, S. A., Alharby, T. A., Abdulmonem, W. A., Musa, K. H., Rasheed, Z., Aljohani, A. S. M., Almujaydil, M. S., Alghonaim, B. Y., Alharbi, N. A., Rajabi, A. A., Khan, M. I., Fernández, N., & Hamad, E. M. (). Camel Milk Supplemented with Fenugreek Seeds Improve Lipid Profile, Atherogenic Index and Antioxidative Status in Animal Model of Cardiovascular Disorders. Pharmacognosy Research, 16(3), 483–489. https://doi.org/10.5530/pres.16.3.58