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    Review

    Exploring the Mechanisms and Dosages of Herbal Hepatoprotective Agents

    Rajendra Prasad Menasagere Rajappa1,2, Paramakrishnan Nallupillai1★, Kamsagara Linganna Krishna3, Manoj Madanahalli Ramesh4, Annegowda Hardur Venkatappa4★ Corresponding author

    1. 1Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Bannimantap, Mysuru, Karnataka, INDIA.
    2. 2Department of Pharmacognosy, Farooqia College of Pharmacy, Mysore, Karnataka, INDIA.
    3. 3Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Bannimantap, Mysuru, Karnataka, INDIA.
    4. 4Department of Pharmacognosy, Sri Adichunchanagiri College of Pharmacy, Faculty of Pharmacy, Adichunchanagiri University, BG Nagara, Mandya, Karnataka, INDIA.

    CORRESPONDENCE

    Paramakrishnan Nallupillai

    Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Bannimantap, Mysuru, Karnataka, INDIA.

    nparamakrishnan@jssuni.edu.in

    Received: 05-07-2024; Revised: 10-07-2024; Accepted: 04-09-2024.

    Volume 16, Issue 4 · pp. 706–717 · PUBLISHED 1 October 2024 · DOI: 10.5530/pres.16.4.82

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Herbal hepatoprotective drugs are important for managing liver health because they provide complementary or alternative treatments for the various disorders of the liver. This review provides a thorough analysis of the numerous herbal hepatoprotective drugs' studied during the recent years, including their modes of action, suggested dosages, market trends, status of clinical trials and patents. The hepatoprotective properties of these herbal medicinal products are partly attributed to their mechanisms of actions such as antioxidant, anti-inflammatory, enzyme-modulating actions, and regeneration of hepatocytes. The recommended dosages differ based on the particular plant and ailment, highlighting the necessity for individualized treatment plans and more research to achieve the best possible therapeutic results. Patented compositions and polyherbal formulations provide novel treatments with synergistic effects that improve medicinal efficacy. The increased demand for natural treatments and their potential applications in pharmaceutical and nutraceutical fields has resulted in a considerable and expanding market for herbal hepatoprotective agents. Notwithstanding their possible advantages, more investigation is required to clarify mechanisms of action, assess long-term safety and efficacy, and provide uniform standards for clinical application. In general, herbal hepatoprotective drugs are promising approaches to manage liver health; nonetheless, their use necessitates regulatory oversight, quality control procedures, and evidence-based practice.

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      Rajappa, R. P. M., Nallupillai, P., Krishna, K. L., Ramesh, M. M., & Venkatappa, A. H. (2024). Exploring the Mechanisms and Dosages of Herbal Hepatoprotective Agents. Pharmacognosy Research, 16(4), 706–717. https://doi.org/10.5530/pres.16.4.82