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    Article

    Green Synthesis of Gold Nanoparticles Using Sphaeranthus amaranthoides: Drug Loading and Anticancer Properties in Nanomedicine

    Iram Shabbir Khan1, Swarnalatha Yanamadala1★, Senthilkumar Chinnaiyan1, Narendran Chiterasu1, Sidhika Kannan1★ Corresponding author

    1. 1Department of Nano Science and Technology, Sathyabama Institute of Science and Technology (Deemed to be University), Chennai, Tamil Nadu, INDIA.

    CORRESPONDENCE

    Swarnalatha Yanamadala

    Dean, Department of Nano Science and Technology, Sathyabama Institute of Science and Technology (Deemed to be University), Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai-600 119, Tamil Nadu, INDIA.

    lokiswarna@gmail.com.

    Received: 20-09-2024; Revised: 26-10-10; Accepted: 03-12-2024.

    Volume 17, Issue 1 · pp. 108–114 · PUBLISHED 2025 · DOI: 10.5530/pres.20251946

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Aim This study introduces a sustainable method for synthesizing anisotropic Sphaeranthus amaranthoides leaf extract reduced gold nanoparticles (S-GNPs) by utilizing the phenolic compounds present in Sphaeranthus amaranthoides leaf extract. Background Unlike conventional chemical methods, this eco-friendly approach leverages natural sunlight as a catalyst and hyaluronic acid for stabilization, providing a green, scalable solution. Objectives The research aims to develop a biocompatible, stable nanoparticle system for targeted cancer drug delivery. Materials and Methods The nanoparticles were synthesized and characterized using Surface Plasmon Resonance (SPR) and High-Resolution Transmission Electron Microscopy (HRTEM) to confirm size, morphology, and zeta potential. Stability was tested in saline solutions at physiological pH. In vivo toxicity studies were conducted using zebra fish larvae, demonstrating high biocompatibility at concentrations below 100 µg/mL. Conclusion Dexamethasone-loaded S-GNPs exhibited significant cytotoxicity against THP-1 Acute Monocytic Leukemia cells, underscoring the potential of this eco-friendly synthesis method for cancer therapy applications. These findings highlight the viability of S-GNPs as effective, biocompatible vehicles for targeted drug delivery, presenting a sustainable alternative to conventional nanoparticle systems.

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      Khan, I. S., Yanamadala, S., Chinnaiyan, S., Chiterasu, N., & Kannan, S. (2025). Green Synthesis of Gold Nanoparticles Using Sphaeranthus amaranthoides: Drug Loading and Anticancer Properties in Nanomedicine. Pharmacognosy Research, 17(1), 108–114. https://doi.org/10.5530/pres.20251946