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    Review

    Amaranthus dubius L.: Ethnomedicinal Significance, Phytochemical Profile, and Therapeutic Potential: A Review

    Bagepalli Srinivas Ashok Kumar1★, Nanjundiya Sadashiva Disha2, Mohammed Khalid3★ Corresponding author

    1. 1Department Pharmacognosy, RL Jalappa College of Pharmacy, Sri Devaraj Urs Academy of Higher Education and Research (A Deemed to be University), Tamaka, Kolar, Karnataka, INDIA.
    2. 2Department Pharmaceutical Chemistry, RL Jalappa College of Pharmacy, Sri Devaraj Urs Academy of Higher Education and Research (A Deemed to be University), Tamaka, Kolar, Karnataka, INDIA.
    3. 3Department Pharmaceutics, RL Jalappa College of Pharmacy, Sri Devaraj Urs Academy of Higher Education and Research (A Deemed to be University), Tamaka, Kolar, Karnataka, INDIA.

    CORRESPONDENCE

    Bagepalli Srinivas Ashok Kumar

    Department Pharmacognosy, RL Jalappa College of Pharmacy, Sri Devaraj Urs Academy of Higher Education and Research, (A Deemed to be University), Tamaka, Kolar, Karnataka, INDIA.

    ashok4vani@gmail.com

    ORCID: 0000-0002-4542-6166

    Received: 09-04-2025; Revised: 14-06-2025; Accepted: 25-08-2025.

    Volume 17, Issue 4 · pp. 1098–1103 · PUBLISHED Oct-Dec 2025 · DOI: 10.5530/pres.20252187

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Amaranthus dubius, also known as red spinach, is widely recognized for its therapeutic potential in traditional medicine, particularly across tropical and subtropical regions. This review compiles and analyses ethnomedicinal, phytochemical, and pharmacological data on A. dubius, underlining its applications in managing various ailments and its potential for development into modern therapeutics. Traditionally, A. dubius has been used to treat conditions such as anaemia, inflammation, digestive disorders, and fever, with high nutritional value reinforcing its role in health maintenance. Phytochemical investigations highlight a spectrum of bioactive compounds, including betacyanins, phenolic acids (e.g., Gallic and Vanillic acids), flavonoids (like quercetin, luteolin, and naringenin), and phytosterols, which are responsible for its broad therapeutic activities. Pharmacological studies have demonstrated that A. dubius possesses potent antioxidant, anti-inflammatory, hepatoprotective, antiviral, and antianemic properties. The antioxidant effects, primarily from its phenolic and flavonoid constituents, protect against oxidative damage, while anti-inflammatory properties aid in modulating immune responses. Recent research indicates that betacyanins from A. dubius exhibit antiviral effects against Dengue Virus Type 2 (DENV-2), and its antianemic activity is supported by evidence showing enhanced haemoglobin levels. Collectively, these findings position A. dubius as a promising source of bioactive compounds for managing chronic diseases, infectious conditions, and inflammation, warranting further research into its mechanisms of action and therapeutic efficacy in clinical settings.

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      Kumar, B. S. A., Disha, N. S., & Khalid, M. (2025). Amaranthus dubius L.: Ethnomedicinal Significance, Phytochemical Profile, and Therapeutic Potential: A Review. Pharmacognosy Research, 17(4), 1098–1103. https://doi.org/10.5530/pres.20252187