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    Secondary metabolites and bioactivities of Myrtus communis

    Mahmoud I. Nassar1★, El-Sayed A. Aboutabl3, Rania F. Ahmed1, Ezzel-Din A. El-Khrisy1, Khaled M. Ibrahim3, Amany A. Sleem2★ Corresponding author

    1. 1aDepartments of Chemistry of Natural Compounds
    2. 2Pharmacology, National Research Centre, Dokki, Cairo, Egypt
    3. 3Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

    CORRESPONDENCE

    Mahmoud I. Nassar

    *Address for correspondence: Dr. Mahmoud I. Nassar, Department of Chemistry of Natural Compounds, National Research Centre, 12622 Dokki, Cairo, Egypt.

    mnassar_eg@yahoo.com

    Received: 22-08-2010; Revised: 23-08-2010; Accepted: 12-01-2011.

    Volume 2, Issue 6 · pp. 325–329 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.75449

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. Methods Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid. Results Determination of the median lethal dose (LD50) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs. Conclusion Administration of extracts of M. communis leaves could be safe at the dose used in this study.

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      Nassar, M. I., Aboutabl, E. A., Ahmed, R. F., El-Khrisy, E. A., Ibrahim, K. M., & Sleem, A. A. (2010). Secondary metabolites and bioactivities of Myrtus communis. Pharmacognosy Research, 2(6), 325–329. https://doi.org/10.4103/0974-8490.75449