Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stress-induced behavioral and biochemical alteration in male albino mice

    D. Jaya Prakash1, S. ArulKumar1, M. Sabesan1★★ Corresponding author

    1. 1aDepartment of Zoology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamilnadu, India

    CORRESPONDENCE

    M. Sabesan

    *Address for correspondence: Dr. M. Sabesan, Professor and wing Head, Department of Zoology, Annamalai University, Annamalainagar – 608 002, Tamilnadu, India.

    sabesan1956@gmail.com

    Received: 29-07-2010; Revised: 15-09-2010; Accepted: 12-01-2011.

    Volume 2, Issue 6 · pp. 330–334 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.75450

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Backgorund Hypericum perforatum extract (HPE), is known for its antidepressant effect. Methods In the present study we investigated the effect of H. perforatum gold nanoparticles (NanohypericumHPGNPs) protective role against restraint stress-induced behavioral and biochemical alterations in mice. Animals were immobilized for a period of 6 hrs/day. HPE (200 mg/kg) and nanohypericum (20 mg/kg) were administered 30 minutes before the animals were subjected to acute immobilized stress. Behavioral test parameters for anxiety and spatial memory were assessed followed by biochemical parmeters (lipid peroxidation, super oxide dismutase, catalase, glutathione peroxidase, reduced glutathione, etc.) subsequently. Results The behavior study showed severe anxiety and memory loss compared to unstressed animals. Biochemical analyses revealed an increase in lipid per oxidation, depletion of super oxide dismutase, reduced glutathione, catalase activity and glutathione per oxidase as compared to unstressed animal. Twenty one days of H. perforatum and nanohypericum treatment in a dose of 200 mg/kg and 20 mg/kg, respectively, significantly attenuated restraint stress-induced behavioral and oxidative damage. Conclusion In conclusion nanohypericum prove the modest activity than the HPE.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Prakash, D. J., ArulKumar, S., & Sabesan, M. (2010). Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stress-induced behavioral and biochemical alteration in male albino mice. Pharmacognosy Research, 2(6), 330–334. https://doi.org/10.4103/0974-8490.75450