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    Acetylcholine and memory-enhancing activity of Ficus racemosa bark

    Faiyaz Ahmed1★, J. N. Narendra Sharath Chandra2, S. Manjunath3★ Corresponding author

    1. 1Nutra Bio Innovations, Vijaynagar, Mysore
    2. 2Nargund College of Pharmacy and Research Foundation, Bangalore
    3. 3Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, India

    CORRESPONDENCE

    Faiyaz Ahmed

    *Address for correspondence: Dr. Faiyaz Ahmed, Nutra Bio Innovations, Vijaynagar 1st Stage, Mysore - 570 017, India.

    fayaz_ahmed09@yahoo.co.in

    Revised: 21-05-2011.

    Volume 3, Issue 4 · pp. 246–249 · PUBLISHED January 2011 · DOI: 10.4103/0974-8490.89744

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder resulting in dementia and enhancement of acetylcholine (Ach) levels in brain using acetylcholinesterase inhibitors is one of the most important approaches for the treatment of AD. Methods In this study, aqueous extract of Ficus racemosa Linn. (Moraceae) bark having anti-infl ammatory, antioxidant, and anticholinesterase activity was evaluated for its ability to enhance Ach levels, and to ascertain its antidementia activity in rats. This work was carried out under the assumption that the F. racemosa extract may show combination of actions which could be beneficial in the treatment of AD, such as neuroprotection, attributed to antioxidant and anti-infl ammatory property and may elevate levels of Ach like Ficus hispida extract reported earlier. Results Administration of the extract at two levels viz., 250 and 500 mg/kg signifi cantly raised (P ≤ 0.05) Ach levels in hippocampi of rats compared to control. The percentage enhancement in Ach levels was found to be 22% and 38%, respectively. Further, the extract at both dosage levels elicited signifi cant reduction (P ≤ 0.05) in transfer latency on elevated plus-maze, which was used as an exteroceptive behavioral model to evaluate memory in rats. Conclusion It is inferred that it would be worthwhile to explore the potential of F. racemosa in the management of Alzheimer disease.

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      Ahmed, F., Chandra, J. N. N. S., & Manjunath, S. (2011). Acetylcholine and memory-enhancing activity of Ficus racemosa bark. Pharmacognosy Research, 3(4), 246–249. https://doi.org/10.4103/0974-8490.89744