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    Antihyperglycemic and antioxidative effects of the hydro-methanolic extract of the seeds of Caesalpinia bonduc on streptozotocin-induced diabetes in male albino rats

    Kishalay Jana1, Kausik Chatterjee1, Kazi Monjur Ali1, Debasis De1, Tushar Kanti Bera1,2, Debidas Ghosh1★★ Corresponding author

    1. 1Department of Bio-Medical Laboratory Science and Management, Andrology, Endocrinology and Molecular Medicine Laboratory, Vidyasagar University, Midnapore
    2. 2Pharmaceutical Division, Southern Health Improvement Samity (SHIS), Bhangar, West Bengal, India

    CORRESPONDENCE

    Debidas Ghosh

    *Address for correspondence: Debidas Ghosh, Department of Bio-Medical Laboratory Science and Management (UGC Innovative Department), Vidyasagar University, Midnapore – 721 102, West Bengal, India.

    debidas_ghosh@yahoo.co.in

    Revised: 29-07-2011.

    Volume 4, Issue 1 · pp. 57–62 · PUBLISHED October-December 2012 · DOI: 10.4103/0974-8490.91044

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background No satisfactory effective treatment is available yet to cure diabetes mellitus. Though, synthetic drugs are used but there are several drawbacks. The attributed antihyperglycemic effects of many traditional plants are due to their ability for the management of diabetes mellitus. Materials and Methods A hydromethanolic extract was administered orally at a dose of 250 mg/kg of body weight per day for 21 days. Its effects on the fasting blood glucose (FBG) level, activities of key carbohydrate metabolic enzymes like hexokinase, glucose-6-phosphatase, and glucose-6-phosphate dehydrogenase, and antioxidant enzymes like catalase and superoxide dismutase along with the effect on the lipid peroxidation level in hepatic tissues were measured. Glycogen levels were also assessed in hepatic and skeletal muscles and some toxicity parameters, such as serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and alkaline phosphates activities were measured. Results Treatment of the hydromethanolic extract of the seeds of Caesalpinia bonduc resulted in a significant (P < 0.05) recovery in the activities of carbohydrate metabolic enzymes along with correction in FBG and glycogen levels as compared with the untreated diabetic group. The extract also resulted in a significant (P < 0.05) recovery in the activities of toxicity assessment enzyme parameters. Activities of antioxidant enzymes like catalase and superoxide dismutase along with the lipid peroxidation levels were also recovered significantly (P < 0.05) after the treatment of the extract. The corrective effects produced by the extract were compared with the standard antidiabetic drug, glibenclamide. Conclusion Our findings provide that the extract shows possible antihyperglycemic and antioxidative activities.

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      Jana, K., Chatterjee, K., Ali, K. M., De, D., Bera, T. K., & Ghosh, D. (2012). Antihyperglycemic and antioxidative effects of the hydro-methanolic extract of the seeds of Caesalpinia bonduc on streptozotocin-induced diabetes in male albino rats. Pharmacognosy Research, 4(1), 57–62. https://doi.org/10.4103/0974-8490.91044