Volume 4, Issue 1

Pharmacognosy Research: The future looks very promising

Ambrose Furey

pp. 1–1 · DOI: 10.4103/0974-8490.91026 · Published October-December 2012

A computational perspective of molecular interactions through virtual screening, pharmacokinetic and dynamic prediction on ribosome toxin A chain and inhibitors of Ricinus communis

R. Barani Kumar, M. Xavier Suresh

pp. 2–10 · DOI: 10.4103/0974-8490.91027 · Published October-December 2012

Background Ricin is considered to be one of the most deadly toxins and gained its favor as a bioweapon that has a serious social and biological impact, due to its widespread nature and abundant availability. The hazardou…

GC-MS analysis of phytocomponents in the ethanol extract of Polygonum chinense L.

Bagavathi Perumal Ezhilan, Ramasamy Neelamegam

pp. 11–14 · DOI: 10.4103/0974-8490.91028 · Published October-December 2012

Background The presence of diverse secondary metabolites has been reported from species of the genus Polygonum. However, there has been not much information available on phytochemical components and biological activity i…

Black tea (Camellia sinensis) decoction shows immunomodulatory properties on an experimental animal model and in human peripheral mononuclear cells

Chandan Chattopadhyay, Nandini Chakrabarti, Mitali Chatterjee, Sonali Mukherjee, Kajari Sarkar, A. Roy Chaudhuri

pp. 15–21 · DOI: 10.4103/0974-8490.91029 · Published October-December 2012

Background Black tea (Camellia sinensis) has been used as a daily beverage for time immemorial. Immunomodulatory effects of tea are recognized as it stimulates the proliferation of cultured human peripheral blood mononuc…

Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test

Katsunori Yamaura, Noriyuki Nakayama, Maki Shimada, Yuanyuan Bi, Hideki Fukata, Koichi Ueno

pp. 22–26 · DOI: 10.4103/0974-8490.91030 · Published October-December 2012

Background Young green barley leaf is one of the richest sources of antioxidants and has been widely consumed for health management in Japan. In this study, we examined whether oral administration of young green barley l…

Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger

Poonam Sharma, Rambir Singh

pp. 27–32 · DOI: 10.4103/0974-8490.91031 · Published October-December 2012

Background Dichlorvos and lindane pesticide causes toxicity in animals including humans. Ginger (Zingiber officinale) is widely used as a culinary medicine in the Ayurvedic system of medicine, possessing a number of phar…

Effect of Butea monosperma Lam. leaves and bark extracts on blood glucose in streptozotocin-induced severely diabetic rats

Faiyaz Ahmed, N. S. Siddaraju, M. Harish, Asna Urooj

pp. 33–36 · DOI: 10.4103/0974-8490.91032 · Published October-December 2012

Background Diabetes mellitus is a chronic metabolic disorder that has significant impact on the health, quality of life and life expectancy, as well as on the health care system. Butea monosperma Lam. Kuntze (Fabaceae), …

Antibacterial activity and the histopathological study of crude extracts and isolated tecomine from Tecoma stans Bignoniaceae in Iraq

Amad M. Al-Azzawi, Ekbal Al-Khateeb, Kulood Al-Sameraei, Alyaa G. Al-Juboori

pp. 37–43 · DOI: 10.4103/0974-8490.91033 · Published October-December 2012

Background Tecoma stans (Bignoniaceae) is a central and south American tree used for the control of diabetes, also known as Yellow Elder, it was collected from the gardens of Al-Jadria in Iraq. Materials and Methods One …

Moringa oleifera Lam.: Protease activity against blood coagulation cascade

A Satish, Sudha Sairam, Faiyaz Ahmed, Asna Urooj

pp. 44–49 · DOI: 10.4103/0974-8490.91034 · Published October-December 2012

Background The present study evaluated the protease activity of aqueous extracts of Moringa oleifera (Moringaceae) leaf (MOL) and root (MOR). Materials and Methods Protease activity was assayed using casein, human plasma…

Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats

Anil U. Tatiya, Sanjay J. Surana, Manisha P. Sutar, Nehal H. Gamit

pp. 50–56 · DOI: 10.4103/0974-8490.91040 · Published October-December 2012

Background Individually Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn. (Euphorbiaceae) and Phyllanthus emblica Linn. single plant extracts have been reported to have hepatoprotective activity. Howe…

Antihyperglycemic and antioxidative effects of the hydro-methanolic extract of the seeds of Caesalpinia bonduc on streptozotocin-induced diabetes in male albino rats

Kishalay Jana, Kausik Chatterjee, Kazi Monjur Ali, Debasis De, Tushar Kanti Bera, Debidas Ghosh

pp. 57–62 · DOI: 10.4103/0974-8490.91044 · Published October-December 2012

Background No satisfactory effective treatment is available yet to cure diabetes mellitus. Though, synthetic drugs are used but there are several drawbacks. The attributed antihyperglycemic effects of many traditional pl…

Identification of the protease inhibitor miraziridine A in the Red sea sponge Theonella swinhoei

Paula Tabares, Björn Degel, Norbert Schaschke, Ute Hentschel, Tanja Schirmeister

pp. 63–72 · DOI: 10.4103/0974-8490.91047 · Published October-December 2012

Background Miraziridine A, a natural peptide isolated from a marine sponge, is a potent cathepsin B inhibitor with a second-order rate constant of 1.5 x 104 M-1 s-1. In the present study, miraziridine A was isolated from…