Anti-inflammatory and anti-hyperalgesic activities of Acanthopanax trifoliatus (L) Merr leaves

ABSTRACT

Context Acanthopanax trifoliatus is a ginseng-like plant, which has been widely used to treat various diseases including inflammatory-related diseases. Aims The present study has been designed to investigate the anti-inflammatory and anti-hyperalgesic effects of various fractions of Acanthopanax trifoliatus leaves ethanolic extract in rats. Materials and Methods Anti-inflammatory activity was studied by using carrageenan-induced edema on rat paw whilst anti-hyperalgesic was assessed by using carrageenan-evoked thermal hyperalgesia on plantar test. Statistical Analysis Used Data were analyzed using Student t-test to compare with control.Multiple comparisons for difference between control and extract-treated groups were evaluated by Tukey HSD (Honestly Significant Difference) test. P values less than 0.05 (P < 0.05) is considered significant. Results Among three different fractions i.e., hexane, dichloromethane, and methanol tested, methanolic fraction displayed the most potent fraction amongst those three. It gave significant anti-inflammatory effect at highest dose, 500 mg/kg, with 77.24% of inhibition. Whilst for anti-hyperalgesic activity, methanolic fraction showed the highest efficacy at 375 mg/kg. Administration of methanolic fraction of Acanthopanax trifoliatus inhibited paw edema in a dose- dependent manner. The inhibition for both activities might be due to possible composition of polar compounds, which are flavonoids and phenolics content. Conclusions Methanol fraction of Acanthopanax trifoliatus leaves has potential effect as anti-inflammatory and anti-hyperalgesia in acute inflammation model.

KEYWORDS

• Acanthopanax trifoliatus
• anti-hyperalgesic carrageenan-evoked thermal hyperalgesia
• plantar test

Showing references and in-text citations exactly as published.

Cite this article

• DOI10.4103/0974-8490.110544Copy

RELATED ARTICLES

Matched on volume, issue, section and article type within Pharmacogn. Res..

• Article · VOLUME 5, ISSUE 2The effects of unripe grape extract on systemic blood pressure, nitric oxide production, and response to angiotensin II administrationMehdi Nematbakhsh, Behzad Zolfaghari, Fatemeh Eshraghi, Tahereh Safari, Zahra Pezeshki, Seyyed Mohammad-Ali Sorooshzadeh · pp. 60–64ORIGINAL ARTICLESame type: ArticleSame issue
• Article · VOLUME 5, ISSUE 2Insulin secretion enhancing activity of roselle calyx extract in normal and streptozotocin-induced diabetic ratsEamruthai Wisetmuen, Patchareewan Pannangpetch, Bunkerd Kongyingyoes, Upa Kukongviriyapan, Wiboonchai Yutanawiboonchai, Arunporn Itharat · pp. 65–70ORIGINAL ARTICLESame type: ArticleSame issue
• Article · VOLUME 5, ISSUE 2Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fractionChinampudur V. Chandrasekaran, Kannan Sundarajan, Jothie R. Edwin, Giligar M. Gururaja, Deepak Mundkinajeddu, Amit Agarwal · pp. 71–79ORIGINAL ARTICLESame type: ArticleSame issue
• Article · VOLUME 5, ISSUE 2Secondary metabolites and bioactivities of Albizia anthelminticaTahia K. Mohamed, Mahmoud I. Nassar, Ahmed H. Gaara, Walaa A. El-Kashak, Iñaki Brouard, Sayed A. El-Toumy · pp. 80–85ORIGINAL ARTICLESame type: ArticleSame issue