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    Hepatoprotective activity of Ficus religiosa leaves against isoniazid+rifampicin and paracetamol induced hepatotoxicity

    Sundaramoorthi Angala Parameswari1★, Challa Madhusudhana Chetty2, Kothapalli Bannoth Chandrasekhar3★ Corresponding author

    1. 1Departments of Pharmaceutical Analysis
    2. 2Biotechnology, Annamacharya College of Pharmacy, Andhra Pradesh
    3. 3Department of Chemistry, JNT University Anantapur, Andhra Pradesh, India

    CORRESPONDENCE

    Sundaramoorthi Angala Parameswari

    *Address for correspondence: Asst. Prof. S. Angala Parameswari, Department of Pharmaceutical Analysis, Annamacharya College of Pharmacy, Andhra Pradesh, India.

    eswarialagusundaram@gmail.com

    Revised: 25-08-2012.

    Volume 5, Issue 4 · pp. 271–276 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.118828

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background The present study was designed to investigate the hepato protective effect of methanolic extract of Ficus religisoa L., Moraceae, on isoniazid-rifampicin and paracetamol induced hepatotoxicity in rats. Materials and Methods Male Wistar albino rats were divided into six groups; group 1 served as a control received vehicle (Distilled water), group 2 served as a toxic control, received isoniazid-rifampicin (100 mg/ kg, i.p.) or paracetamol 200mg/kg, p.o in sterile water, groups 3, 4 and 5 received 100, 200 and 300mg/kg bw, p.o. methanolic extract of F. religisoa along with INH+RIF or paracetamol and group 6 received Liv 52 as reference standard. All the treatment protocols followed 21 days for INH+RIF model and seven days for paracetamol model, after treatment rats were sacrificed and blood was used for biochemical and liver was used for histological studies. Results Administration of INH+RIF and paracetamol caused a significant elevation in the levels of liver marker enzymes (P < 0.05 and P < 0.01) and thiobarbituric acid reactive substances (P < 0.001) in experimental rats. Administration of methanolic extracts of F. religisoa significantly prevented isoniazid-rifampicin and paracetamol induced elevation in the levels of serum diagnostic liver marker enzymes and TBARS level in experimental groups of rats. Moreover, total protein and reduced glutathione levels were significantly (P < 0.001) increased in treatment group. The effect of extract was compared with a standard drug, Liv 52. The changes in biochemical parameters were supported by histological profile. Conclusion The methanolic extract of F. religisoa protects against isoniazid- rifampicin and paracetamol induced oxidative liver injury in rats.

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      Parameswari, S. A., Chetty, C. M., & Chandrasekhar, K. B. (2013). Hepatoprotective activity of Ficus religiosa leaves against isoniazid+rifampicin and paracetamol induced hepatotoxicity. Pharmacognosy Research, 5(4), 271–276. https://doi.org/10.4103/0974-8490.118828