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    Modulatory of effect of fresh Amaranthus caudatus and Amaranthus hybridus aqueous leaf extracts on detoxify enzymes and micronuclei formation after exposure to sodium arsenite

    Adetutu Adewale1★, Awe Emmanuel Olorunju2★ Corresponding author

    1. 1Departments of Biochemistry
    2. 2Departments of Pharmacology and Therapeutic, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

    CORRESPONDENCE

    Adetutu Adewale

    *Address for correspondence: Dr. Adetutu Adewale, Department of Biochemistry, Faculty of Basic Medical Sciences College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.

    aadetutu@lautech.edu.ng

    Revised: 28-02-2013.

    Volume 5, Issue 4 · pp. 300–305 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.118819

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Vegetables are the cheapest and most available sources of important proteins, minerals, vitamins, and essential amino protein. These vegetables are commonly used in Africa for the treatment of illness. This study evaluated the protective effects of Amaranthus caudatus and A. hybridus against sodium arsenite-induced toxicity in rats. The effects of sodium arsenite and/or the plant extracts were assessed using bone marrow micronucleus assay and by measuring the activities of tumour maker enzymes such as gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) in white albino Wister rats. The study showed that sodium arsenite significantly (P < 0.05) induced the formation of micronucleated polychromatic erythrocytes and the activities of ALP and GGT when compared with control. The levels of white blood cell, hemoglobin, and lymphocyte count were altered in sodium arsenite fed rats and were reverted back to near normal levels in rats pretreated with the plant extracts. A. caudatus and A. hybridus showed significant role in protecting the detoxifying enzymes; also, A. caudatus has a more protective effect on reducing the micronuclei formation when compared with A. hybridus. This study suggests that A. caudatus and A. hybridus possess anticarcinogenic effect.

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      Adewale, A., & Olorunju, A. E. (2013). Modulatory of effect of fresh Amaranthus caudatus and Amaranthus hybridus aqueous leaf extracts on detoxify enzymes and micronuclei formation after exposure to sodium arsenite. Pharmacognosy Research, 5(4), 300–305. https://doi.org/10.4103/0974-8490.118819