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    The hypoglycemic effect of the aqueous extract of the fruits of Balanites aegypticea in Alloxan-induced diabetic rats

    Abdella Emam Abdella Baragob1, Waleed Hassan AlMalki1, Imran Shahid1★, Fatimah Abdullah Bakhdhar1, Hanouf Saeed Bafhaid1, Omar Muhammad Izz Eldeen2★ Corresponding author

    1. 1Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al Qura University, P. O. Box 13174, Makkah, The kingdom of Saudi Arabia
    2. 2Faculty of Science and Technology, Omdurman Islamic University, Khartoum, Republic of Sudan

    CORRESPONDENCE

    Imran Shahid

    *Address for correspondence: Dr. Imran Shahid, Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al Qura University, P. O. Box 13174, Makkah, The kingdom of Saudi Arabia.

    iyshahid@uqu.edu.sa

    Revised: 26-08-2013.

    Volume 6, Issue 1 · pp. 1–5 · PUBLISHED January-March 2014 · DOI: 10.4103/0974-8490.122909

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Balanites aegypticea is used medically for many purposes e.g. anti-spasmodic, stomach pain, malaria, and yellow fever. The extract of the fruit is also used to reduce the blood glucose levels. Objectives The objective of this study was to investigate the hypoglycemic effects of the aqueous extract of the fruits of the Balanites aegypticea in alloxan-induced diabetic rats. Materials and Methods Twenty-five adult male Vistar rats were used in this study. The rats were randomly collected and divided into 5 groups (5 rats in each group). The untreated rats (negative control group) received basal diet and tap water only for 15 days. The experimental rats became diabetic by intraperitoneal injection of alloxan (150 mg/kg body weight). The fruit of Balanites aegypticea was powdered, extracted, and dried using organic solvents. The diabetic rats received aqueous extract 200 mg/kg, 400 mg/kg, and 800 mg/kg, respectively, for 2 weeks. Plasma glucose levels were measured by using Glucose GOD-PAP method through spectrophotometer. Results The results showed that 800 mg/kg aqueous extract decrease significantly the plasma glucose level (P ≤ 0.05) in diabetic rats, and there is a considerable gain in body weight (P ≤ 0.05) compared to the diabetic control group. Four-hundred mg/kg aqueous extract has a mild effect on body weights and plasma glucose levels, while 200 mg/kg aqueous extract has no significant effect on plasma glucose level and a little effect on body weight. Conclusions The results of the presented study revealed that the aqueous extract of Balanites aegypticea has hypoglycemic properties. It can decrease the plasma glucose level and can improve weight in diabetic experimental animals.

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      Baragob, A. E. A., AlMalki, W. H., Shahid, I., Bakhdhar, F. A., Bafhaid, H. S., & Eldeen, O. M. I. (2014). The hypoglycemic effect of the aqueous extract of the fruits of Balanites aegypticea in Alloxan-induced diabetic rats. Pharmacognosy Research, 6(1), 1–5. https://doi.org/10.4103/0974-8490.122909