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    The efficacy of ginger added to ondansetron for preventing postoperative nausea and vomiting in ambulatory surgery

    Pragnadyuti Mandal1, Anjan Das2★, Saikat Majumdar3, Tapas Bhattacharyya2, Tapobrata Mitra4, Ratul Kundu5★ Corresponding author

    1. 1Department of Pharmacology, Midnapore Medical College, Paschim Medinipur
    2. 2Departments of Anaesthesiology, College of Medicine and Sagore Dutta Hospital
    3. 3NRS Medical College
    4. 4Bangur Institute of Neurology
    5. 5I.P.G.M.E.R, Kolkata, West Bengal, India

    CORRESPONDENCE

    Anjan Das

    *Address for correspondence: Dr. Anjan Das, 174 Gorakshabashi Road, Royal Plaza Apartment, Nagerbazar, Kolkata - 28, West Bengal, India.

    anjan2k8@yahoo.com

    Revised: 20-08-2013.

    Volume 6, Issue 1 · pp. 52–57 · PUBLISHED January-March 2014 · DOI: 10.4103/0974-8490.122918

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Post-operative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many costly antiemetic drugs and regimens. Objective The study was carried out to compare the efficacy of ginger (Zingiber officinale) added to Ondansetron in preventing PONV after ambulatory surgery. Materials and Methods It was a prospective, double blinded, and randomized controlled study. From March 2008 to July 2010, 100 adult patients of either sex, aged 20-45, of ASA physical status I and II, scheduled for day care surgery, were randomly allocated into Group A[(n = 50) receiving (IV) Ondansetron (4 mg) and two capsules of placebo] and Group B[(n = 50) receiving IV Ondansetron (4 mg) and two capsules of ginger] simultaneously one hour prior to induction of general anaesthesia (GA) in a double-blind manner. One ginger capsule contains 0.5 gm of ginger powder. Episodes of PONV were noted at 0.5h, 1h, 2h, 4h, 6h, 12h and 18h post- operatively. Statistical Analysis and Results Statistically significant difference between groups A and B (P < 0.05), was found showing that ginger ondansetron combination was superior to plain Ondansetron as antiemetic regimen for both regarding frequency and severity. Conclusion Prophylactic administration of ginger and ondansetron significantly reduced the incidence of postoperative nausea and vomiting compared to ondansetron alone in patients undergoing day care surgery under general anaesthesia.

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      Mandal, P., Das, A., Majumdar, S., Bhattacharyya, T., Mitra, T., & Kundu, R. (2014). The efficacy of ginger added to ondansetron for preventing postoperative nausea and vomiting in ambulatory surgery. Pharmacognosy Research, 6(1), 52–57. https://doi.org/10.4103/0974-8490.122918