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    Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats

    Akram Ranjbar1★, Fariba Mohsenzadeh2, Abdolkarim Chehregani2, Farzad Khajavi3, Seyed-Mostafa Hossini Zijoud4, Hassan Ghasemi4★ Corresponding author

    1. 1Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences
    2. 2Biology, Laboratory of Plant Cell Biology
    3. 3Department of Chemistry, Bu-Ali Sina University
    4. 4Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    CORRESPONDENCE

    Akram Ranjbar

    *Address for correspondence: Dr. Akram Ranjbar, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, 6517838678, Iran.

    akranjbar1389@yahoo.com

    Revised: 25-10-2013.

    Volume 6, Issue 3 · pp. 199–203 · PUBLISHED July-September 2014 · DOI: 10.4103/0974-8490.132595

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity. Materials and Methods Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured. Results In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx. Conclusion M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.

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      Ranjbar, A., Mohsenzadeh, F., Chehregani, A., Khajavi, F., Zijoud, S. H., & Ghasemi, H. (2014). Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats. Pharmacognosy Research, 6(3), 199–203. https://doi.org/10.4103/0974-8490.132595