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    Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats

    Himanshu Bhusan Sahoo1, Saroj Kumar Sahoo2, Sarada Prasad Sarangi3, Rakesh Sagar4, Mohan Lal Kori5★★ Corresponding author

    1. 1Departments of Pharmacology and Experimental Biology, Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh
    2. 2Departments of Pharmaceutical Chemistry, Sri Sivani College of Pharmacy, Srikakulam
    3. 3Jayamukhi Institute of Pharmaceutical Science, Warangal, Andhra Pradesh
    4. 4Departments of Pharmacognosy and Phytochemistry, Sri Satya Sai Institute of Pharmaceutical Sciences
    5. 5Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India

    CORRESPONDENCE

    Mohan Lal Kori

    *Address for correspondence: Dr. Mohan Lal Kori, Department of Pharmacognosy and Phytochemistry, Vedica College of Pharmacy, Bhopal - 462 033, Madhya Pradesh, India.

    mohanlalkori@gmail.com

    Revised: 05-01-2014.

    Volume 6, Issue 3 · pp. 204–209 · PUBLISHED July-September 2014 · DOI: 10.4103/0974-8490.132596

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Cuminum cyminum Linn. (Umbelliferae), commonly known as Jeera. It is native from mediterranean region, but today widely cultivated in Asian countries. It has been reported to possess various medicinal properties and an important food ingredient. The seed of the plant are claimed for treatment of diarrhoea by various traditional practitioners. Objectives Hence, the present investigation was undertaken to evaluate aq. extract of C. cyminum seeds (ACCS) against diarrhoea on albino rats. Materials and Methods The animals were divided into five groups and the control group was applied with 2% acacia suspension, the standard group with loperamide (3 mg/kg) or atropine sulphate (5mg/kg) and three test groups administered orally with 100, 250 and 500 mg/kg of ACCS. The antidiarrhoeal effect was investigated by castor oil induce diarrhoea model, prostaglandin E2 (PGE2) induced enteropooling model, intestinal transit by charcoal meal test. Results The ACCS showed significant (P < 0.001) inhibition in frequency of diarrhoea, defecation time delaying, secretion of intestinal fluid as well as intestinal propulsion as compared to control and the graded doses of tested extract followed dose dependent protection against diarrhoea. Conclusions The study reveals that the ACCS is a potent antidiarrhoeal drug which supports the traditional claim.

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      Sahoo, H. B., Sahoo, S. K., Sarangi, S. P., Sagar, R., & Kori, M. L. (2014). Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats. Pharmacognosy Research, 6(3), 204–209. https://doi.org/10.4103/0974-8490.132596