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    A New Antimicrobial Prenylated Benzo-lactone from the Rhizome of Cissus cornifolia

    Aliyu M. Musa1, Nasir Tajuddeen2★, Abdullahi Y. Idris1, Abdurahman Y. Rafindadi1, Musa I. Abdullahi5, Abubakar B. Aliyu2, Mikhail S. Abdullahi4, Mohammed A. Ibrahim3★ Corresponding author

    1. 1Departments of Pharmaceutical and Medicinal Chemistry
    2. 2Chemistry
    3. 3Biochemistry Ahmadu Bello University
    4. 4Directorate of research, Nigeria Institute of Leather and Science Technology, Zaria
    5. 5Department of Pharmaceutical and Medicinal Chemistry, Usmanu Danfodio University, Sokoto, Nigeria

    CORRESPONDENCE

    Nasir Tajuddeen

    *Address for correspondence: Mr. Nasir Tajuddeen, Department of Chemistry Ahmadu Bello University, Zaria, Nigeria.

    ntajuddeen@yahoo.com

    Revised: 18-02-2015.

    Volume 7, Issue 4 · pp. 363–366 · PUBLISHED October-December 2015 · DOI: 10.4103/0974-8490.159572

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Medicinal plants remain one of the largest reservoirs of new bioactive compounds. In this study, a new prenylated benzo-lactone (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one) was isolated from the acetone extracts of the rhizome of Cissus cornifolia. The antimicrobial activity of the compound was evaluated against some microorganisms including Staphylococcus aureus, Salmonella typhi, and Candida albicans. Materials and Methods The acetone extracts of the rhizome of C. cornifolia was separated and purified by various chromatographic techniques. The structure of the isolated compound was characterized by analysis of spectral data including one and two- dimensional nuclear magnetic resonance. Results The isolated compound was characterized as (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)- one), it showed activity against 6 out of 10 tested clinical isolates of some microorganisms including S. aureus, S. typhi, and C. albicans. The inhibition zones ranged between 17 mm and 25 mm. The inhibition zones observed compare favorably with the positive control used. Conclusion The compound could serve as a lead for the development of more potent antimicrobial agent. To the best of our knowledge, this is the first report of the isolation and characterization as well as antimicrobial screening of the compound.

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      Musa, A. M., Tajuddeen, N., Idris, A. Y., Rafindadi, A. Y., Abdullahi, M. I., Aliyu, A. B., Abdullahi, M. S., & Ibrahim, M. A. (2015). A New Antimicrobial Prenylated Benzo-lactone from the Rhizome of Cissus cornifolia. Pharmacognosy Research, 7(4), 363–366. https://doi.org/10.4103/0974-8490.159572