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    Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae)

    Kokou Anani1,2,4★, Yao Adjrah1,2,4, Yaovi Améyapoh1,2, Simplice Damintoti Karou1,2,4, Amegnona Agbonon2,3, Comlan de Souza1,2, Messanvi Gbeassor2,3★ Corresponding author

    1. 1Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA)
    2. 2Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM)
    3. 3Laboratoire de Physiologie et de Pharmacologie, Faculté des Sciences, Université de Lomé, B.P. 1515
    4. 4Centre de Recherche en Agriculture Biologique et Substances Naturelles (CRABISNA)

    CORRESPONDENCE

    Kokou Anani

    Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires, Ecole Supérieure des Techniques Biologiques et Alimentaires, Université de Lomé, B.P. 1515, Lomé, Togo. Centre de Recherche et de Formation sur les Plantes Médicinales, Université de Lomé, B.P. 1515, Lomé, Togo.

    kokouanani@gmail.com

    Volume 8, Issue 2 · pp. 142–146 · PUBLISHED Apr-Jun 2016 · DOI: 10.4103/0974-8490.172657

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Jatropha multifida is used in Togolease folk medicine for the healing of chronic wounds. Objective This study aims to investigate antibacterial, anti-inflammatory and antioxidant activities of the leaves ethanolic extract. Materials and Methods The antimicrobial activity was assayed by National Committee for Clinical Laboratory Standards broth microdilution method on strains of Staphylococcus aureus and Pseudomoas aeruginosa isolated from wounds, whereas the anti-inflammatory activity was performed by carrageenan and histamine induced paw edema method in rat modele. The 2, 2-diphenyl- 1picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) were used for the antioxidant activity. Results The antibacterial assay showed an in vitro growth inhibition of P. aeruginosa and S. aureus in dose-dependent manner, with minimum inhibitory concentration values ranging from 2.5 to 3.12 mg/mL for S. aureus and from 6.25 to 12.5 mg/mL for P. aeruginosa. The maximum paw anti-inflammatory effect occurred after 3 and 5 h administration of histamine and carrageenan, respectively. The DPPH radical scavenging and the FRAP assays yielded weak antioxidant activity. Conclusion J. multifida possesses antibacterial and anti-inflammatory activities that could justify the use of the plant for the treatment of wounds in the folk medicine.

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      Anani, K., Adjrah, Y., Améyapoh, Y., Karou, S. D., Agbonon, A., Souza, C. D., & Gbeassor, M. (2016). Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae). Pharmacognosy Research, 8(2), 142–146. https://doi.org/10.4103/0974-8490.172657