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    Free Radicals and AntioxidantsNOW IN
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    Hepatoprotective mechanisms of Ageratum conyzoides L. on oxidative damage induced by acetaminophen in Wistar rats

    Pawan Kumar Verma1★, Rajinder Raina1, Mudasir Sultana1, Shahid Prawez1, Neha Jamwal1★ Corresponding author

    1. 1Division of Veterinary Pharmacology & Toxicology, Faculty of Veterinary Sciences & Animal Husbandry, SKUAST, Jammu 181102, J&K, India.

    CORRESPONDENCE

    Pawan Kumar Verma

    Division of Veterinary Pharmacology & Toxicology, Faculty of Veterinary Sciences & Animal Husbandry, SKUAST, Jammu 181102, J&K, India.

    drpawankv@yahoo.co.in

    Received: 28-03-2013; Revised: 23-05-2013; Accepted: 20-08-2013.

    Volume 3, Issue 2 · pp. 73–76 · PUBLISHED · DOI: 10.1016/j.fra.2013.05.009

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Background and objectives: Drug induced hepatotoxicity is a major health issue concern by drug regu- latory agencies, pharmaceutical industry and health care professionals. Present study was aimed to investigate the hepatoprotective mechanisms of n-hexane and acetone extract of Ageratum conyzoides on oxidative damage induced by acetaminophen (APAP) in Wistar rats. Materials and methods: 42 Wistar rats were randomly divided into seven groups. Group I and II receive distilled water, CMC respectively. Group III was fed with standard drug silymarin, group IV and V received plant extracts only whereas group VI and VII received pretreatment with acetone and n-hexane extracts for seven days respectively and APAP was administered on the 5th day. Samples were collected on 48 h of post APAP administration and analysis was done using standard protocols.Results: Significant (p < 0.05) increased in MDA, G6PD and GST and significant (p < 0.05) decrease in SOD, GSH, total thiols in liver tissue was observed in APAP exposed group as compared to control. The pre- exposure of acetone and n-hexane extracts of A. conyzoides fallowed by APAP exposure significantly (p < 0.05) reduce activities of G6PD, GST and MDA levels as compare to APAP exposed group, whereas total thiols and GSH levels are restored only in n-hexane extract of A. conyzoides. Conclusion: Observations of present study suggested that pre-exposure of n-hexane extract of A. conyzoides restore the levels of total thiols, GSH and GST activity which may be responsible for reducing oxidative damage induced by APAP administration.

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      Verma, P. K., Raina, R., Sultana, M., Prawez, S., & Jamwal, N. (). Hepatoprotective mechanisms of Ageratum conyzoides L. on oxidative damage induced by acetaminophen in Wistar rats. Free Radicals and Antioxidants, 3(2), 73–76. https://doi.org/10.1016/j.fra.2013.05.009