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    Free Radicals and AntioxidantsNOW IN
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    Newcastle disease virus (NDV) modulates pro/antioxidant status in different brain regions of chicken

    Kadiam C. Venkata Subbaiah1, Rajendra Wudayagiri2, Lokanatha Valluru1★★ Corresponding author

    1. 1Department of Biotechnology, Dravidian University, Kuppam, A.P 517 426, India.
    2. 2Department of Zoology, Sri Venkateswara University, Tirupati, A.P 517 502, India.

    CORRESPONDENCE

    Lokanatha Valluru

    Department of Biotechnology, Dravidian University, Kuppam, A.P 517 426, India.

    lokanathav@yahoo.co.in

    Received: 18-03-2013; Revised: 23-05-2013; Accepted: 20-08-2013.

    Volume 3, Issue 2 · pp. 81–86 · PUBLISHED · DOI: 10.1016/j.fra.2013.05.006

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Background:Newcastle disease (ND) is highly contagious disease caused by Newcastle disease virus (NDV) causes mass mortalities in poultry and triggers poultry economy. Methods: NDV induced oxidative stress representing marker enzymes and lipid peroxidation levels were evaluated in tissues of control and virus infected animals by using standard protocols and methods. Results: Lipid peroxidation levels were significantly increased in cerebrum and cerebellum of NDV infected chickens on 10 (dpi) as compared to controls. The activities of superoxide dismutase, catalase and glutathione metabolism representing enzymes were significantly decreased in cerebrum and cere- bellum. Extensive histopathological malformations were observed in cerebrum and cerebellum. Conclusion: The results of the present study, thus demonstrated that region specific alterations in the antioxidant defense mechanism due to NDV infection suggesting its critical role in cellular injury prominently in cerebrum and cerebellum and moderately in optic lobes of brain. The findings could help to advance the therapeutic armamentarium for control of Newcastle disease in poultry.

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      Subbaiah, K. C. V., Wudayagiri, R., & Valluru, L. (). Newcastle disease virus (NDV) modulates pro/antioxidant status in different brain regions of chicken. Free Radicals and Antioxidants, 3(2), 81–86. https://doi.org/10.1016/j.fra.2013.05.006