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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Comparison Between Dexamethasone and Fentanyl as an Adjuvant to Bupivacaine and Lignocaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery

    Shilpa Sarang Kore1, Smita Bhau Ubhe1, Fathima Fasil1★★ Corresponding author

    1. 1Department of Anaesthesia, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.

    CORRESPONDENCE

    Fathima Fasil

    Department of Anaesthesia, Dr. D. Y. Patil Medical College, Hospital and Research centre, Pimpri, Pune, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra 411018, India.

    drfthma@gmail.com

    Received: 07-12-2021; Revised: 05-01-2022; Accepted: 28-01-2022.

    Volume 13, Issue 1 · pp. 59–65 · PUBLISHED 2022 · DOI: 10.1177/0976500X221085803

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objective: To compare the effects of dexamethasone and fentanyl when added to a mixture of bupivacaine and lignocaine in supraclavicular blocks in patients undergoing forearm surgeries. Methods: Sixty-six patients aged between 20 to 60 years old belonging to ASA one or two were recruited prospectively, double-blinded, and randomized way. Supraclavicular block under sonographic guidance was performed in the three groups by using injection bupivacaine (0.5%) 20 cc + injection lignocaine (2%) 10 cc + injection 0.9% normal saline; 2ml (Group S), injection bupivacaine (0.5%) 20 cc + injection lignocaine (2%) 10 cc + injection dexamethasone 8 mg (Group D), and injection bupivacaine (0.5%) 20 cc + injection lignocaine (2%) 10 cc + injection fentanyl 50 μgm (Group F). The onset time of sensory and motor block, duration of sensory and motor block, and hemodynamic variables were recorded. Results: Group D showed a significantly greater sensory and motor block duration than other groups (P = 0.001). Comparison of hemodynamic variables failed to reveal any statistically significant differences between all the groups. Conclusion: Both dexamethasone and fentanyl are good adjuvants in the supraclavicular block, but dexamethasone is better, given faster onset and duration of analgesia.

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      Kore, S. S., Ubhe, S. B., & Fasil, F. (2022). Comparison Between Dexamethasone and Fentanyl as an Adjuvant to Bupivacaine and Lignocaine in Supraclavicular Brachial Plexus Block for Upper Limb Surgery. Journal of Pharmacology and Pharmacotherapeutics, 13(1), 59–65. https://doi.org/10.1177/0976500X221085803