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    Article

    α‑Glucosidase Inhibitory Activity from Ethyl Acetate Extract of Antidesma bunius (L.) Spreng Stem Bark Containing Triterpenoids

    Marista Gilang Mauldina1, Rani Sauriasari1★, Berna Elya1★ Corresponding author

    1. 1Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.

    CORRESPONDENCE

    Rani Sauriasari

    Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.

    rani@farmasi.ui.ac.id

    Received: 25-01-2017; Revised: 06-03-2017.

    Volume 13, Issue 52 · pp. 590–594 · PUBLISHED 13 November 2017 · DOI: 10.4103/pm.pm_25_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Buni (Antidesma bunius [L.] Spreng) has been used as a traditional antidiabetic agent in Asia. Objective: The mechanism of antidiabetic properties was studied in this study by determine its α‑glucosidase inhibitory activity. Method: Inhibition of α‑glucosidase was performed in all fraction of Buni stem bark with acarbose and miglitol as standards. The half maximal inhibitory concentration (IC50) value of acarbose and miglitol was 5.75 and 59.76 μg/mL respectively while ethyl acetate (EtOAc) fraction was the most active fraction with IC50 of 19.33 μg/mL. Three isolates (B1, B2, and B3) were found in the EtOAc fraction and elucidated by infrared, 1hydrogen‑nuclear magnetic resonance, 13carbon‑nuclear magnetic resonance, and two‑dimensional nuclear magnetic resonance. Result: The chemical structures of the isolates were identified by the spectrum then compared with literature which concluded that B1 is friedelin, B2 is β‑sitosterol, and B3 is betulinic acid. Inhibition of the α‑glucosidase assay showed IC50 values of B1, B2, and B3 were 19.51, 49.85, and 18.49 μg/mL, respectively.

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      Mauldina, M. G., Sauriasari, R., & Elya, B. (2017). α‑Glucosidase Inhibitory Activity from Ethyl Acetate Extract of Antidesma bunius (L.) Spreng Stem Bark Containing Triterpenoids. Pharmacognosy Magazine, 13(52), 590–594. https://doi.org/10.4103/pm.pm_25_17