Mice Behavioral Phenotype Changes after Administration of Anani (Symphonia globulifera, Clusiaceae), an Alternative Latin American and African Medicine
Ivana Barbosa Suffredini2★, Mateus Luís Barradas Paciencia2, Ingrit E. C. Díaz3, Sergio Alexandre Frana2, Maria Martha Bernardi2★ Corresponding author
- 1Center for Research in Biodiversity Extraction Laboratory and Herbarium, Graduate Program in Environmental and Experimental Pathology and Graduate Program in Dentistry, Paulista University, São Paulo, Brazil.
- 2Chemistry and Textile Engineer Faculdty from the National University of Engineer, Lima, Peru.
CORRESPONDENCE
Ivana Barbosa Suffredini
Chemistry and Textile Engineer Faculdty from the National University of Engineer, Lima, Peru.
Received: 28-04-2017; Revised: 25-07-2017.
Volume 13, Issue 52 · pp. 617–626 · PUBLISHED 13 November 2017 · DOI: 10.4103/pm.pm_168_17
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ABSTRACT
Background: Anani, (Symphonia globulifera, Clusiaceae), known as chewstick, is a traditional plant occurring in Africa and in Central and South Americas that is used against parasites and microorganisms. Although its use is popular in some of these countries, there is a lack of information related to its influence over behavioral phenotype (BP). Objective: The objective of this study is to evaluate the influence of the administration of the extract obtained from the aerial organs of Anani (EB1257) to male Balb‑c mice over BP. Materials and Methods: Open cage observation, open field, and elevated‑plus maze apparatuses were used. Evaluations were done 15, 30, 60, 120, and 180 min after intraperitoneal administration of Anani extract. Results: Impairment of general behavior activity, response to touch, tail squeeze, defecation, locomotion and rearing frequency were observed although no signs of hemorrhage or macroscopical alterations of internal organs. Anani is harmful, but not toxic if used in the appropriate doses, yet to be determined to male mice. Impairment of locomotion and defecation was observed, indicating some degree of influence over locomotion, but no alterations in anxiety levels were assessed. Three compounds were previously found in the plant‑lupeol (1), β‑amyrin (2) and 3‑β‑hydroxyglutin‑5‑ene (3), and one is being described for the first time to occur in the species: oleanolic acid (4). Conclusions: The present work contributes in the support of the rational use of Anani, an important Latin American and African alternative medicine, presenting findings that are being reported for the first time.
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Suffredini, I. B., Paciencia, M. L. B., Díaz, I. E. C., Frana, S. A., & Bernardi, M. M. (2017). Mice Behavioral Phenotype Changes after Administration of Anani (Symphonia globulifera, Clusiaceae), an Alternative Latin American and African Medicine. Pharmacognosy Magazine, 13(52), 617–626. https://doi.org/10.4103/pm.pm_168_17