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    Article

    Further Study of Influence of Panax notoginseng on Intestinal Absorption Characteristics of Triptolide and Tripterine in Rats with Tripterygium wilfordii

    Yiqun Li1, Benyong Zhang2, Mengzhu Liu3, Xinlong Zhang3, Donglei Shi3, Liwei Guo3, Jinao Duan3, Xueping Zhou3, Huaxu Zhu3★, Qichun Zhang3★★ Corresponding author

    1. 1Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China.
    2. 2Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China.
    3. 3Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.

    CORRESPONDENCE

    Huaxu Zhu

    Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.

    zhuhx@njucm.edu.cn, zhangqc@njucm.edu.cn

    Received: 06-03-2017; Revised: 03-05-2017; Accepted: 20-02-2018.

    Volume 14, Issue 53 · pp. 95–102 · PUBLISHED 20 February 2018 · DOI: 10.4103/pm.pm_67_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Tripterygium wilfordii (TW) is widely employed to treat rheumatoid arthritis and autoimmune disorders clinically, which, however, accompany with disturbing hepatotoxicity and nephrotoxicity. The previous research showed that Panax notoginseng (PN) compatibly and significantly reduces the TW-induced hepatotoxicity. Objective: To explore the underlying mechanism, the present study was designed to reveal the influence of PN on the intestinal absorption process of TW-derived active components in rat. Materials and Methods: An in situ single-pass intestinal perfusion technique was established and preformed to obtain the perfusate samples of triptolide (TP), tripterine (TE), TW extract, and TW-PN extract. A rapid and sensitive ultra-performance liquid-chromatography tandem mass spectrometry method was subsequently developed and validated to determine the concentrations of TP and TE in the perfusate samples. Then, the absorption parameters, effective permeability, absorption rate constant, and percentage of 10 cm intestinal absorption were calculated strictly. Results: The final data indicated that both TP and TE have no special absorption site in the intestine and are primarily absorbed in a passive manner. Otherwise, the absorption of TP was decreased from compatibility of PN, but the absorption of TE was enhanced. Conclusion: The absorption reduction of TP and absorption elevation of TE from TW initiated by the combination of PN are contributed to attenuate the toxicity and reinforce the therapeutic efficacy of TW. It is practically reasonable of usage of TW compatibility with PN clinically.

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      Li, Y., Zhang, B., Liu, M., Zhang, X., Shi, D., Guo, L., Duan, J., Zhou, X., Zhu, H., & Zhang, Q. (2018). Further Study of Influence of Panax notoginseng on Intestinal Absorption Characteristics of Triptolide and Tripterine in Rats with Tripterygium wilfordii. Pharmacognosy Magazine, 14(53), 95–102. https://doi.org/10.4103/pm.pm_67_17