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    Article

    Comparative Effects of Metformin, Pleurotus ostreatus, Nigella Sativa, and Zingiber officinale on the Streptozotocin‑induced Diabetes Mellitus in Rats

    Sibghatullah Muhammad Ali Sangi1★, Abdulhakim Bawadekji2, Mouhanad Al Ali3★ Corresponding author

    1. 1Department of Clinical Pharmacy, Faculty of Pharmacy, Northern Border University, Rafha, 1 Deanship of Scientific Research, Northern Border University, Arar, 2 Institut Supérieur de la Sante et des Bioproduits d’Angers, Université d’Angers, Angers, France, Kingdom of Saudi Arabia.

    CORRESPONDENCE

    Sibghatullah Muhammad Ali Sangi

    Department of Clinical Pharmacy, Faculty of Pharmacy, Northern Border University, Rafha, 1 Deanship of Scientific Research, Northern Border University, Arar, 2 Institut Supérieur de la Sante et des Bioproduits d’Angers, Université d’Angers, Angers, France, Kingdom of Saudi Arabia.

    doctor_sangi@yahoo.com

    Received: 20-03-2018; Revised: 11-04-2018.

    Volume 14, Issue 55s · pp. S268–S273 · PUBLISHED 28 June 2018 · DOI: 10.4103/pm.pm_108_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Diabetes mellitus (DM) is a heterogeneous metabolic disorder occurring due to absolute or relative deficiency of insulin and causing chronic hyperglycemia that leads to crippling complications associated with morbidity and mortality. Objectives: The objective of the present work is to investigate the comparative antihyperglycemic effects of Pleurotus ostreatus, Nigella sativa, and Zingiber officinale with metformin. Materials and Methods: The study was conducted from June 2017 to February 2018. In this study, rats were divided into six groups according to the treatment regimen. Each group comprised five rats. Serum analysis of glucose was conducted during the treatment. After animals were sacrificed, histopathological examination of the pancreas was carried out. Results: Histopathological examination showed that streptozotocin caused damage to pancreatic beta‑cells which secrete the insulin. Treatment with metformin, N. sativa, mushroom, and ginger produced a significant improvement in the function of these cells, regeneration of cells, and decrease in serum glucose levels. Conclusion: In two groups, N. sativa and ginger, regeneration of beta islets was observed, along with a significant reduction in the serum glucose levels, which was found in other groups as well.

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      Sangi, S. M. A., Bawadekji, A., & Ali, M. A. (2018). Comparative Effects of Metformin, Pleurotus ostreatus, Nigella Sativa, and Zingiber officinale on the Streptozotocin‑induced Diabetes Mellitus in Rats. Pharmacognosy Magazine, 14(55s), S268–S273. https://doi.org/10.4103/pm.pm_108_18