New Formulation Containing Curcuminoids: Method Validation and Dissolution Profile
Nayara Luiza Oliveira Ferreira1★, Mariana Cristina Morais Rodrigues1, Rejanne Lima Arruda1, Pierre Alexandre Santos1★ Corresponding author
- 1Maria Teresa Freitas Bara, Edemilson Cardoso Conceição Bioproducts Research, Development and Innovation Laboratory, School of Pharmacy, Federal University of Goias, Goiania, Brazil.
CORRESPONDENCE
Nayara Luiza Oliveira Ferreira
Maria Teresa Freitas Bara, Edemilson Cardoso Conceição Bioproducts Research, Development and Innovation Laboratory, School of Pharmacy, Federal University of Goias, Goiania, Brazil.
Received: 31-01-2018; Revised: 09-03-2018.
Volume 15, Issue 60 · pp. 73–80 · PUBLISHED 23 January 2019 · DOI: 10.4103/pm.pm_50_18
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ABSTRACT
Objective: The aim of this work was to obtain capsules using C. longa soft extract, to develop and validate a method for quantification of curcuminoids, and to study the dissolution profile of the capsules. Materials and Methods: The liquid extract was obtained through the percolation method and concentrated until it is characterized as soft extract. A high‑performance liquid chromatography (HPLC) method was developed and validated for quantification of curcuminoids in the soft extract. The granule was obtained through wet granulation process and was encapsulated and the method for quantification of the markers was covalidated. Results: The soft extract showed 3.45% of bisdemethoxycurcumin, 3.03% of demethoxycurcumin, and 14.83% of curcumin, corresponding to 21.31% of total curcuminoids. The capsules had an average weight of 420 mg with approximately 21.56 mg of curcuminoids. The capsules showed better dissolution profile in neutral medium that simulates the pH of duodenum; however, in the stability test, only the variation found for bisdemethoxycurcumin was in compliance with the permitted. Conclusions: A soft extract of C. longa standardized in the three main curcuminoids was produced, as well as hard gelatinous capsules containing a dose of 21.56 mg of total curcuminoids. Thus, a new phytotherapeutic formulation was proposed, which proves to be an interesting strategy to carry out the active principles of C. longa.
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Ferreira, N. L. O., Rodrigues, M. C. M., Arruda, R. L., & Santos, P. A. (2019). New Formulation Containing Curcuminoids: Method Validation and Dissolution Profile. Pharmacognosy Magazine, 15(60), 73–80. https://doi.org/10.4103/pm.pm_50_18