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    Polysaccharides from Radix Astragali Exert Immunostimulatory Effects to Attenuate the Dampness Stagnancy Due to Spleen Deficiency Syndrome

    Wenxiao Zhao2,3, Lijun Chen2, Ning Cui4, Xuming Ji5, Haiqiang Jiang6, Tiantian Deng4, Shijun Wang3,4★★ Corresponding author

    1. 1School of Nursing, Shandong University of Traditional Chinese Medicine, China.
    2. 2Shandong Co-Innovation Center of Classic Traditional Chinese Medicine Formula, China.
    3. 3School of Traditional Chinese Medical, Shandong University of Traditional Chinese Medicine, China.
    4. 4College of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
    5. 5Key Laboratory of Traditional Chinese Medicine Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

    CORRESPONDENCE

    Shijun Wang

    School of Traditional Chinese Medical, Shandong University of Traditional Chinese Medicine, China.

    pathology@163.com

    Received: 30-09-2018; Revised: 09-11-2018.

    Volume 15, Issue 63 · pp. 500–506 · PUBLISHED 16 May 2019 · DOI: 10.4103/pm.pm_503_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The objective of the study is to investigate the potential mechanism of action of APS underlying attenuating water and fluid retention of rats with the DSSD syndrome in order to provide novel insights into the application of APS on modulating the DSSD syndrome. Materials and Methods: Four‑week‑old Wistar rats were fed with one high‑fat and low‑protein diet and subjected to exhaustive swimming to induce the DSSD model for 8 weeks. APS (300, 600, and 1200 mg/kg) and Shen Ling Bai Zhu San (SLBZS) (2.5 g/kg) were administrated starting at 9 weeks for 2 weeks. Results: APS increased the body weight, decreased the water load index, and attenuated symptoms of the DSSD syndrome. APS also increased spleen and thymus indices, the percentage of CD3+, the percentage of CD3+ CD4+, and CD3+ CD4+ to CD3+ CD8+ ratio and decreased levels of serum interleukin (IL)‑6, IL‑10, and tumor necrosis factor‑α in DSSD rats. Significant effects were seen for toll‑like receptor 4 (TLR4) at both protein and gene expression levels with amelioration of expression levels in APS groups. Conclusion: These findings suggest that APS may be used to attenuate the fluid retention of the DSSD syndrome through the immunoregulatory effect, which is driven in part by the modulation of TLR4.

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      Zhao, W., Chen, L., Cui, N., Ji, X., Jiang, H., Deng, T., & Wang, S. (2019). Polysaccharides from Radix Astragali Exert Immunostimulatory Effects to Attenuate the Dampness Stagnancy Due to Spleen Deficiency Syndrome. Pharmacognosy Magazine, 15(63), 500–506. https://doi.org/10.4103/pm.pm_503_18