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    Article

    Undulaterpene A: A New Triterpene Fatty Acid Ester from Pulicaria undulata

    Hossam Mohamed Abdallah2,3, Gamal A. Mohamed2,4★, Sabrin R. M. Ibrahim5,6, Hani Z. Asfour7, Maan T. Khayat8★ Corresponding author

    1. 1Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
    2. 2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo.
    3. 3Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
    4. 4Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah, Saudi Arabia.
    5. 5Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
    6. 6Department of Medical Microbiology and Parasitology, Faculty of Medicine, Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University.
    7. 7Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

    CORRESPONDENCE

    Gamal A. Mohamed

    Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo.

    hmafifi@kau.edu.sa

    Received: 28-12-2018; Revised: 12-02-2019.

    Volume 15, Issue 65 · pp. 671–674 · PUBLISHED 19 September 2019 · DOI: 10.4103/pm.pm_668_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: In this work, the chemical investigation of Pulicaria undulata aerial parts was performed. In addition, the cytotoxic activity of the isolated metabolites was estimated toward various cell lines. Materials and Methods: Plant extract was subjected to fractionation and different column chromatography to isolate the biometabolites. Their structures were verified using nuclear magnetic resonance, infrared, ultraviolet, and high‑resolution mass spectrometry, as well as compared with the literature. The cytotoxic effect was evaluated in vitro toward various cell lines: HCT‑116 (colorectal adenocarcinoma), MCF‑7 (human breast adenocarcinoma), and A549 (lung carcinoma). Results: A new triterpene fatty acid ester, undulaterpene A (1) (3β,16β‑dihydroxylup‑20 (29)‑ene 3‑decanoate) and four known metabolites: 3‑O‑acetyl‑pseudotaraxasterol (2), pseudotaraxasterol (3), stigmasterol (4), and tomentosin (5) were separated. Compound 1 displayed cytotoxic potential toward hormone-dependent breast carcinoma cell line (MCF7), colon carcinoma cell line (HCT116), and lung carcinoma cell line (A549) cell lines with half maximal inhibitory concentrations (IC50s) 8.2, 6.9, and 12.4 µM, respectively in comparison to doxorubicin (IC50s 0.14, 0.39, and 1.15 µM, respectively). However, 2, 3, and 4 displayed activity toward HCT‑116 with IC50s 13.2, 23.1, and 16.4 µM, respectively. Conclusion: This work led to the identification of a new triterpene fatty acid ester (1) and four known metabolites (2–5) from P. undulata growing in Saudi Arabia. The new compound showed moderate cytotoxic potential against hormone- dependent breast carcinoma cell line (MCF7), colon carcinoma cell line (HCT116), and lung carcinoma cell line (A549) cancer cell lines.

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      Abdallah, H. M., Mohamed, G. A., Ibrahim, S. R. M., Asfour, H. Z., & Khayat, M. T. (2019). Undulaterpene A: A New Triterpene Fatty Acid Ester from Pulicaria undulata. Pharmacognosy Magazine, 15(65), 671–674. https://doi.org/10.4103/pm.pm_668_18