Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Protective Effect of Fucoxanthin on Ovariectomy‑Induced Osteoporosis in Rats

    Lichun Guo2, Minyan Dang3, Qichun Song4, Wenzhi Zhang3, Bing Li5★★ Corresponding author

    1. 1Department of Orthopaedics, The Second Affiliated Hospital of Xi’an Medical University, No.167, Fangdong Street, Baqiao District, Xi’an, Shaanxi Province, 710038, China.
    2. 2Innoscience Research Sdn Bhd,Subang Jaya, 47650 Selangor, Malaysia.
    3. 3Department of Orthopaedics,Shaanxi Provincial People’s Hospital, No.256, West Youyi Road, Beilin District, Xi’an, Shaanxi Province, 710068, China.
    4. 4Department of orthopedic, Xi’an No.3 Hospital, No. 10, East Section of Fengcheng 3rd Road, Weiyang District, Xi’an, Shaanxi Province, 710018, China.

    CORRESPONDENCE

    Bing Li

    drxj1018@sina.com

    Received: 30-07-2019; Revised: 04-09-2019; Accepted: 17-02-2020.

    Volume 16, Issue 69 · pp. 242–249 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_340_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: We planned to investigate the therapeutic effect of fucoxanthin on ovariectomy‑stimulated osteoporosis in experimental rats. Hence, the study is conducted to evaluate the protective effect of fucoxanthin against ovariectomy‑induced osteoporosis in female Sprague Dawley (SD) rats. Materials and Methods: Healthy adult female SD rats weighing about 230–245 g were randomized into four groups of six animals each. Group I served as sham‑operated control. Group II served as model (ovariectomized [OVX]) rats. OVX rats were administered with fucoxanthin at a dose of 20 mg/kg and 40 mg/kg orally for 16 weeks which served as Group III and Group IV, respectively. Results: A significant increase in body weight and decrease in uterine index was observed in OVX rats, whereas treatment with fucoxanthin substantially reverted the body weight and uterine mass. Bone turnover markers (Ca, P, and osteocalcin), levels of estrogen and 1,25‑dihydroxycholecalciferol 1,25(OH)2D3, osteoprotegerin and receptor activator of nuclear factor‑κB ligand, and inflammatory markers were reverted back to a significant extent by treatment with fucoxanthin. The biomechanical stability of bones was significantly increased with administration of fucoxanthin. The findings were also substantiated by histopathological analysis. Conclusion: Based on the outcome of the results, it can be concluded that fucoxanthin showed better protection against osteoporosis by improving bone mineral content and bone density in addition to biomechanical parameters.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Guo, L., Dang, M., Song, Q., Zhang, W., & Li, B. (2020). Protective Effect of Fucoxanthin on Ovariectomy‑Induced Osteoporosis in Rats. Pharmacognosy Magazine, 16(69), 242–249. https://doi.org/10.4103/pm.pm_340_19