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    Article

    Protective Effect of Adropin against High Fat Diet‑induced Obese Diabetic Wistar Rats via Nuclear Factor Erythroid 2‑related Factor 2 Pathway

    Fang Luo1★, Qing‑Chu Li1, Feng‑Jiao Zhang1, Lei Li1, Li‑Ge Song1, Yu Mao1, Jing Li1, Hong‑Mei Liu1, Feng‑Li Li1, Ling‑Yu Xu1★ Corresponding author

    1. 1Ya‑Jie Huo, Huan‑Huan Wang, Zhi‑Qiang Kang, Li He Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou City, Henan Province, China.

    CORRESPONDENCE

    Fang Luo

    Ya‑Jie Huo, Huan‑Huan Wang, Zhi‑Qiang Kang, Li He Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou City, Henan Province, China.

    helizhongxin@sina.cn

    Received: 28-09-2019; Revised: 10-10-2019; Accepted: 17-02-2020.

    Volume 16, Issue 69 · pp. 250–257 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_434_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>. Materials and Methods: The methanolic extract of <em>C. arnottiana</em> leaves was evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, and hydroxyl radical scavenging assays. Anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. Results: The extract showed significant antioxidant activity in a dose-dependent manner. In the anti-inflammatory assay, the extract at 200 and 400 mg/kg doses significantly reduced paw edema compared to the control group. Conclusion: <em>C. arnottiana</em> possesses significant antioxidant and anti-inflammatory properties, supporting its traditional use.

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      Luo, F., Li, Q., Zhang, F., Li, L., Song, L., Mao, Y., Li, J., Liu, H., Li, F., & Xu, L. (2020). Protective Effect of Adropin against High Fat Diet‑induced Obese Diabetic Wistar Rats via Nuclear Factor Erythroid 2‑related Factor 2 Pathway. Pharmacognosy Magazine, 16(69), 250–257. https://doi.org/10.4103/pm.pm_434_19