Charantin Relieves Pain by Inhibiting Pro‑Inflammatory Cytokine Induction
Jaewon Shim2, Jae Goo Kim2, Eun Yeong Lim2,3, Yun Tai Kim2,3★★ Corresponding author
- 1Research Division of Food Functionality, Korea Food Research Institute, Wanju‑Gun, Jeollabuk‑Do.
- 2Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Korea.
CORRESPONDENCE
Yun Tai Kim
Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Korea.
Received: 06-08-2019; Revised: 04-09-2019; Accepted: 14-02-2020.
Volume 16, Issue 69 · pp. 282–287 · PUBLISHED 11 June 2020 · DOI: 10.4103/pm.pm_348_19
View on Pharmacogn. Mag. original site ↗
ABSTRACT
Objectives: Because there have been little reports on charantin’s role as an analgesic, we evaluated its pain relief effect to determine if it could be a novel pain killer candidate. Materials and Methods: We established post-operative and neuropathic pain models, which represent acute and chronic pain, respectively. Mechanical withdrawal threshold assay and ultrasonic vocalization analysis were used as behavioral tests. Results: The administration of charantin reduced both the post-operative and neuropathic pain. The application of charantin did not make a difference in the activation of action potentials of dorsal root ganglion (DRG) neurons. However, charantin inhibited the induction of the pro‑inflammatory cytokines interleukin IL-12 and IL‑1β in DRG neurons. Conclusion: Our findings indicate that charantin seems to relieve pain by inhibiting the inflammatory process rather than by directly influencing the activity of neurons. We conclude that charantin, the commercially available extract from M. charantia, has great efficacy as a novel analgesic compound.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Shim, J., Kim, J. G., Lim, E. Y., & Kim, Y. T. (2020). Charantin Relieves Pain by Inhibiting Pro‑Inflammatory Cytokine Induction. Pharmacognosy Magazine, 16(69), 282–287. https://doi.org/10.4103/pm.pm_348_19