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    Article

    Evaluation of Anti-inflammatory and Antioxidant Activities of Cissus quadrangularis Stem Extract

    Ahmed Al-Ghamdi1★, Mohammed Al-Saeed1★ Corresponding author

    1. 1Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

    CORRESPONDENCE

    Ahmed Al-Ghamdi

    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

    aalghamdi@ksu.edu.sa

    Received: 04-06-2019; Revised: 10-10-2019; Accepted: 19-11-2019.

    Volume 16, Issue 69 · pp. 321–328 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_222_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> L. is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) stem. Materials and Methods: The anti-inflammatory activity was evaluated using the carrageenan-induced rat paw edema model. The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, and total phenolic content (TPC) determination. Results: MECQ showed significant anti-inflammatory activity in a dose-dependent manner. In the antioxidant assays, MECQ exhibited strong DPPH radical scavenging activity (IC50 = 45.23 μg/mL) and high FRAP value. The TPC was found to be 124.5 mg gallic acid equivalent/g of extract. Conclusion: The results suggest that <em>Cissus quadrangularis</em> possesses significant anti-inflammatory and antioxidant activities, which may be attributed to its phenolic content.

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      Al-Ghamdi, A., & Al-Saeed, M. (2020). Evaluation of Anti-inflammatory and Antioxidant Activities of Cissus quadrangularis Stem Extract. Pharmacognosy Magazine, 16(69), 321–328. https://doi.org/10.4103/pm.pm_222_19